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    Tnfaip1 TNF alpha induced protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 287543, updated on 9-Dec-2024

    Summary

    Official Symbol
    Tnfaip1provided by RGD
    Official Full Name
    TNF alpha induced protein 1provided by RGD
    Primary source
    RGD:3877
    See related
    EnsemblRapid:ENSRNOG00000009069 AllianceGenome:RGD:3877
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Edp1
    Summary
    Enables cyclin binding activity. Involved in positive regulation of DNA replication. Predicted to be located in endosome. Predicted to be part of Cul3-RING ubiquitin ligase complex. Orthologous to human TNFAIP1 (TNF alpha induced protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 202.5), Kidney (RPKM 199.0) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Tnfaip1 in Genome Data Viewer
    Location:
    10q25
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (63915824..63930514, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (63417774..63432466, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (65791002..65805693, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene transmembrane protein 199 Neighboring gene DNA polymerase delta interacting protein 2 Neighboring gene intraflagellar transport 20 Neighboring gene transmembrane protein 97

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cyclin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables small GTPase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    contributes_to ubiquitin-protein transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    contributes_to ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to ubiquitin-protein transferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in immune response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in immune response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of Rho protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of Rho protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of Rho protein signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of DNA replication IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein homooligomerization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in stress fiber assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in stress fiber assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    part_of Cul3-RING ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of Cul3-RING ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of Cul3-RING ubiquitin ligase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2
    Names
    BTB/POZ domain-containing protein TNFAIP1
    tumor necrosis factor, alpha induced protein 1
    tumor necrosis factor, alpha-induced protein 1 (endothelial)
    tumor necrosis factor-induced protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_182950.4NP_891995.1  BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2

      See identical proteins and their annotated locations for NP_891995.1

      Status: PROVISIONAL

      Source sequence(s)
      BC128704
      UniProtKB/Swiss-Prot
      Q7TNY1
      UniProtKB/TrEMBL
      A6HH59
      Related
      ENSRNOP00000012245.3, ENSRNOT00000012245.6
      Conserved Domains (1) summary
      cd18401
      Location:26129
      BTB_POZ_TNFAIP1_BACURD2; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in tumor necrosis factor, alpha-induced protein 1, endothelial (TNFAIP1)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      63915824..63930514 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)