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    Slc30a1 solute carrier family 30 member 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 58976, updated on 27-Nov-2024

    Summary

    Official Symbol
    Slc30a1provided by RGD
    Official Full Name
    solute carrier family 30 member 1provided by RGD
    Primary source
    RGD:61918
    See related
    EnsemblRapid:ENSRNOG00000004749 AllianceGenome:RGD:61918
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables calcium channel inhibitor activity and zinc:proton antiporter activity. Involved in several processes, including detoxification of cadmium ion; metal ion transport; and regulation of postsynapse organization. Acts upstream of or within zinc ion transport. Located in T-tubule; dendrite; and postsynaptic density. Is active in Schaffer collateral - CA1 synapse and postsynaptic density membrane. Orthologous to human SLC30A1 (solute carrier family 30 member 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Liver (RPKM 355.5), Kidney (RPKM 321.6) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Slc30a1 in Genome Data Viewer
    Location:
    13q27
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (106022019..106025892)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (103491037..103494910)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (110677810..110681683)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120096356 Neighboring gene NIMA-related kinase 2 Neighboring gene uncharacterized LOC108352598 Neighboring gene uncharacterized LOC120096357

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium channel inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables calcium channel inhibitor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables calcium channel inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables zinc ion transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables zinc ion transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables zinc ion transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables zinc:proton antiporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cadmium ion transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in calcium ion import IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in defense response to bacterium ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in defense response to bacterium ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in detoxification of cadmium ion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in detoxification of zinc ion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within in utero embryonic development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intracellular calcium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intracellular zinc ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within intracellular zinc ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intracellular zinc ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intracellular zinc ion homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of calcium ion import ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of neurotransmitter secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of zinc ion transmembrane import ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of dendritic spine morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of postsynaptic density protein 95 clustering IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in zinc export across plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in zinc export across plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in zinc ion import into organelle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in zinc ion import into organelle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in zinc ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within zinc ion transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in zinc ion transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in zinc ion transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in zinc ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in Schaffer collateral - CA1 synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in T-tubule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in basolateral plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic vesicle membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in glutamatergic postsynaptic density IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in postsynaptic density membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in postsynaptic density, intracellular component IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    proton-coupled zinc antiporter SLC30A1
    Names
    solute carrier family 30 (zinc transporter), member 1
    zinc transporter 1
    znT-1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022853.2NP_074044.1  proton-coupled zinc antiporter SLC30A1

      See identical proteins and their annotated locations for NP_074044.1

      Status: PROVISIONAL

      Source sequence(s)
      U17133
      UniProtKB/Swiss-Prot
      Q62720
      Related
      ENSRNOP00000006340.2, ENSRNOT00000006340.6
      Conserved Domains (2) summary
      COG1230
      Location:6422
      CzcD; Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]
      pfam01545
      Location:21343
      Cation_efflux; Cation efflux family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      106022019..106025892
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)