Unc119 unc-119 lipid binding chaperone [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Unc119provided by RGD
Official Full Name: unc-119 lipid binding chaperoneprovided by RGD
Primary source: RGD:3942
See related: EnsemblRapid:ENSRNOG00000011060 AllianceGenome:RGD:3942
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RRG4; Uncl19
Summary: Predicted to enable lipid binding activity. Predicted to be involved in several processes, including lipoprotein transport; negative regulation of endocytosis; and positive regulation of protein tyrosine kinase activity. Predicted to be located in cytoplasm. Predicted to be active in intercellular bridge and microtubule cytoskeleton. Human ortholog(s) of this gene implicated in cone-rod dystrophy 24 and immunodeficiency 13. Orthologous to human UNC119 (unc-119 lipid binding chaperone). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Heart (RPKM 170.4), Spleen (RPKM 128.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q25

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (63735927..63741404)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (63237862..63243339)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (65606919..65612324)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH129323 (e-PCR)
- UniSTS:212630

RH127571 (e-PCR)
- UniSTS:210881

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables lipid binding	IBA Inferred from Biological aspect of Ancestor more info
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables lipid binding	ISO Inferred from Sequence Orthology more info
enables lipid binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in endocytosis	IEA Inferred from Electronic Annotation more info
involved_in lipoprotein transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in lipoprotein transport	IEA Inferred from Electronic Annotation more info
involved_in lipoprotein transport	ISO Inferred from Sequence Orthology more info
involved_in lipoprotein transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitotic cytokinesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic cytokinesis	IEA Inferred from Electronic Annotation more info
involved_in mitotic cytokinesis	ISO Inferred from Sequence Orthology more info
involved_in mitotic cytokinesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of caveolin-mediated endocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of caveolin-mediated endocytosis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of caveolin-mediated endocytosis	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of clathrin-dependent endocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of clathrin-dependent endocytosis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of clathrin-dependent endocytosis	ISS Inferred from Sequence or Structural Similarity more info
involved_in nervous system development	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in visual perception	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in centrosome	IBA Inferred from Biological aspect of Ancestor more info
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in centrosome	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in intercellular bridge	IBA Inferred from Biological aspect of Ancestor more info
located_in intercellular bridge	IEA Inferred from Electronic Annotation more info
located_in intercellular bridge	ISO Inferred from Sequence Orthology more info
located_in intercellular bridge	ISS Inferred from Sequence or Structural Similarity more info
is_active_in spindle midzone	IBA Inferred from Biological aspect of Ancestor more info
located_in spindle midzone	IEA Inferred from Electronic Annotation more info
located_in spindle midzone	ISO Inferred from Sequence Orthology more info
located_in spindle midzone	ISS Inferred from Sequence or Structural Similarity more info
is_active_in spindle pole	IBA Inferred from Biological aspect of Ancestor more info
located_in spindle pole	IEA Inferred from Electronic Annotation more info
located_in spindle pole	ISO Inferred from Sequence Orthology more info
located_in spindle pole	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: protein unc-119 homolog A

Names: UNC-119 homolog; retinal gene 4; retinal protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017188.1 → NP_058884.1 protein unc-119 homolog A

See identical proteins and their annotated locations for NP_058884.1

Status: PROVISIONAL

Source sequence(s)

U40999

UniProtKB/Swiss-Prot

Q62885

UniProtKB/TrEMBL

A6HH44, A6HH45

Related

ENSRNOP00000015091.5, ENSRNOT00000015091.9

Conserved Domains (1) summary

pfam05351
Location:81 → 236

GMP_PDE_delta; GMP-PDE, delta subunit

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

63735927..63741404

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063268810.1 → XP_063124880.1 protein unc-119 homolog A isoform X1
XM_039085739.2 → XP_038941667.1 protein unc-119 homolog A isoform X2

UniProtKB/TrEMBL

A0A8I6AN70

Related

ENSRNOP00000095078.1, ENSRNOT00000107663.2

Conserved Domains (1) summary

pfam05351
Location:10 → 165

GMP_PDE_delta; GMP-PDE, delta subunit