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    smg-3 MIF4G domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 177397, updated on 9-Dec-2024

    Summary

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    Official Symbol
    smg-3
    Official Full Name
    MIF4G domain-containing protein
    Primary source
    WormBase:WBGene00004881
    Locus tag
    CELE_Y73B6BL.18
    See related
    AllianceGenome:WB:WBGene00004881
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables enzyme binding activity. Involved in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay. Predicted to be part of exon-exon junction complex. Predicted to be active in cytoplasm. Orthologous to human UPF2 (UPF2 regulator of nonsense mediated mRNA decay). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See smg-3 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    16
    Sequence:
    Chromosome: IV; NC_003282.8 (6362395..6373089, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Biogenesis of lysosome-related organelles complex 1 subunit 2 Neighboring gene ncRNA Neighboring gene Protein quiver Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene RRM domain-containing protein Neighboring gene Nematode cuticle collagen N-terminal domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The allele-specific suppressor sup-39 alters use of cryptic splice sites in Caenorhabditis elegans. Roller AB, et al. Genetics, 2000 Mar. PMID 10757761, Free PMC Article
    2. Contribution of the amino and carboxyl termini for PHA-4/FoxA function in Caenorhabditis elegans. Kaltenbach LS, et al. Dev Dyn, 2005 Oct. PMID 16127716
    3. SMG-1 is a phosphatidylinositol kinase-related protein kinase required for nonsense-mediated mRNA Decay in Caenorhabditis elegans. Grimson A, et al. Mol Cell Biol, 2004 Sep. PMID 15314158, Free PMC Article
    4. Suppressors of the unc-73 gene of Caenorhabditis elegans. Run JQ, et al. Genetics, 1996 May. PMID 8722777, Free PMC Article
    5. Functional analysis of an intron 3' splice site in Caenorhabditis elegans. Zhang H, et al. RNA, 1996 Apr. PMID 8634918, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of exon-exon junction complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    MIF4G domain-containing protein
    NP_001368064.1
    • Confirmed by transcript evidence
    NP_500974.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      6362395..6373089 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_068573.10 → NP_500974.2  MIF4G domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_500974.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EDT8
      Conserved Domains (2) summary
      pfam04050
      Location:957 → 1098
      Upf2; Up-frameshift suppressor 2
      cl02652
      Location:650 → 827
      MIF4G; MIF4G domain

    2. NM_001380273.1 → NP_001368064.1  MIF4G domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      C2BR97
      Conserved Domains (2) summary
      pfam04050
      Location:960 → 1100
      Upf2; Up-frameshift suppressor 2
      cl02652
      Location:650 → 827
      MIF4G; MIF4G domain
    Nucleotide Protein
    Heading Accession and Version

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