Hexd hexosaminidase D [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Hexdprovided by RGD
Official Full Name: hexosaminidase Dprovided by RGD
Primary source: RGD:2302323
See related: EnsemblRapid:ENSRNOG00000036667 AllianceGenome:RGD:2302323
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Hexdc
Summary: Predicted to enable beta-N-acetylhexosaminidase activity. Predicted to be involved in carbohydrate metabolic process. Predicted to be located in cytoplasm; extracellular vesicle; and nucleus. Orthologous to human HEXD (hexosaminidase D). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 164.2), Spleen (RPKM 114.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q32.3

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (106978426..107002252)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (106479781..106498799)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (110406431..110425042)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables beta-N-acetylglucosaminidase activity	IEA Inferred from Electronic Annotation more info
enables beta-N-acetylhexosaminidase activity	ISO Inferred from Sequence Orthology more info
enables hexosaminidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables hexosaminidase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in extracellular vesicle	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: hexosaminidase D

Names: hexosaminidase (glycosyl hydrolase family 20, catalytic domain) containing; hexosaminidase D, catalytic domain containing

NP_001136034.2

EC 3.2.1.52

XP_038940913.1

EC 3.2.1.52

XP_063124301.1

EC 3.2.1.52

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001142562.2 → NP_001136034.2 hexosaminidase D

See identical proteins and their annotated locations for NP_001136034.2

Status: VALIDATED

Source sequence(s)

BC158670, CR464043, DN931298

UniProtKB/TrEMBL

B0BN37, F1LR76

Related

ENSRNOP00000051807.2, ENSRNOT00000054924.5

Conserved Domains (1) summary

cd06565
Location:9 → 323

GH20_GcnA-like; Glycosyl hydrolase family 20 (GH20) catalytic domain of N-acetyl-beta-D-glucosaminidase (GcnA, also known as BhsA) and related proteins. GcnA is an exoglucosidase which cleaves N-acetyl-beta-D-galactosamine (NAG) and N-acetyl-beta-D-galactosamine ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

106978426..107002252

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063268231.1 → XP_063124301.1 hexosaminidase D isoform X1

UniProtKB/TrEMBL

B0BN37, F1LR76
XM_039084985.2 → XP_038940913.1 hexosaminidase D isoform X2

Conserved Domains (1) summary

cl02948
Location:1 → 195

GH20_hexosaminidase; Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides. ...