U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    ndua-8 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [ Caenorhabditis elegans ]

    Gene ID: 175371, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    ndua-8
    Official Full Name
    NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8
    Primary source
    WormBase:WBGene00021849
    Locus tag
    CELE_Y54F10AM.5
    See related
    AllianceGenome:WB:WBGene00021849
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in mitochondrial respiratory chain complex I assembly. Predicted to be located in mitochondrial inner membrane. Predicted to be part of respiratory chain complex I. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency. Orthologous to human NDUFA8 (NADH:ubiquinone oxidoreductase subunit A8). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See ndua-8 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    4
    Sequence:
    Chromosome: III; NC_003281.10 (2529063..2530502)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Secreted protein Neighboring gene WD_REPEATS_REGION domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene Homeobox protein cut-like ceh-44 Neighboring gene Protein CASP Neighboring gene ncRNA Neighboring gene Amyloid beta A4 precursor protein-binding family B member 2-like;Protein Fe65 homolog

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Subcomplex Ilambda specifically controls integrated mitochondrial functions in Caenorhabditis elegans. Falk MJ, et al. PLoS One, 2009 Aug 12. PMID 19672299, Free PMC Article
    2. Gene regulatory network inference in long-lived C. elegans reveals modular properties that are predictive of novel aging genes. Suriyalaksh M, et al. iScience, 2022 Jan 21. PMID 35036864, Free PMC Article
    3. RNA targets and specificity of Staufen, a double-stranded RNA-binding protein in Caenorhabditis elegans. LeGendre JB, et al. J Biol Chem, 2013 Jan 25. PMID 23195953, Free PMC Article
    4. A genome-wide study of PDZ-domain interactions in C. elegans reveals a high frequency of non-canonical binding. Lenfant N, et al. BMC Genomics, 2010 Nov 26. PMID 21110867, Free PMC Article
    5. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in mitochondrial electron transport, NADH to ubiquinone IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial respiratory chain complex I assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of respiratory chain complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of respiratory chain complex I IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8
    NP_497574.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      2529063..2530502
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_065173.5 → NP_497574.2  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_497574.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9BL03
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools