Septin3 septin 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Septin3provided by RGD
Official Full Name: septin 3provided by RGD
Primary source: RGD:621745
See related: EnsemblRapid:ENSRNOG00000007686 AllianceGenome:RGD:621745
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Sep3; Sept3
Summary: Enables GTP binding activity. Predicted to be involved in cytoskeleton-dependent cytokinesis; protein catabolic process at presynapse; and protein localization. Located in presynaptic membrane. Is active in presynapse. Orthologous to human SEPTIN3 (septin 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 296.4) and Testes (RPKM 25.4) See more
Orthologs: human mouse all
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Genomic context

Location:: 7q34

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (115659414..115691173)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (113783217..113811089)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (123506535..123526542)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Septin 3 localizes in the membrane microdomains of the synaptic plasma membrane in adult brain and may have important roles in the membrane dynamics of neurons.
Title: Biochemical characterization of membrane-associated septin from rat brain.
Sept3 is a neurone-specific developmentally regulated protein highly enriched in nerve terminals which supports a secretory role in synaptic vesicle recycling.
Title: Septin 3 (G-septin) is a developmentally regulated phosphoprotein enriched in presynaptic nerve terminals.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GTP binding	IDA Inferred from Direct Assay more info	PubMed
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables molecular adaptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cytoskeleton-dependent cytokinesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein catabolic process at presynapse	ISO Inferred from Sequence Orthology more info
involved_in protein localization	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cell division site	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
is_active_in microtubule cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
is_active_in presynapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynapse	ISO Inferred from Sequence Orthology more info
located_in presynapse	ISO Inferred from Sequence Orthology more info
is_active_in presynaptic cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
part_of septin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of septin complex	ISO Inferred from Sequence Orthology more info
part_of septin complex	ISS Inferred from Sequence or Structural Similarity more info
is_active_in septin ring	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: neuronal-specific septin-3

Names: G-septin alpha; P40

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019375.2 → NP_062248.2 neuronal-specific septin-3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000007

UniProtKB/Swiss-Prot

Q9R245, Q9WU34, Q9WU35

UniProtKB/TrEMBL

A0A8I6A6E2, A6HT54

Conserved Domains (1) summary

cd01850
Location:59 → 333

CDC_Septin; CDC/Septin GTPase family