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    glt-1 Excitatory amino acid transporter [ Caenorhabditis elegans ]

    Gene ID: 180641, updated on 9-Dec-2024

    Summary

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    Official Symbol
    glt-1
    Official Full Name
    Excitatory amino acid transporter
    Primary source
    WormBase:WBGene00001620
    Locus tag
    CELE_C12D12.2
    See related
    AllianceGenome:WB:WBGene00001620
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables L-glutamate transmembrane transporter activity. Predicted to be involved in L-glutamate transmembrane transport. Located in cell projection. Is expressed in body wall musculature; cephalic sheath cell; hypodermis; and muscle cell. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 41. Orthologous to human SLC1A2 (solute carrier family 1 member 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See glt-1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    9
    Sequence:
    Chromosome: X; NC_003284.9 (3496026..3499169)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene BI1-like protein Neighboring gene IgGFc_binding domain-containing protein Neighboring gene HMG box domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structure and activity of a new form of the glutamate transporter of the nematode Caenorhabditis elegans. Kawano T, et al. Biosci Biotechnol Biochem, 1997 May. PMID 9178573
    2. Cloning and characterization of cDNAs encoding putative glutamate transporters from Caenorhabditis elegans and Onchocerca volvulus. Radice AD, et al. Mol Biochem Parasitol, 1996 Sep. PMID 8885221
    3. Glutamate spillover in C. elegans triggers repetitive behavior through presynaptic activation of MGL-2/mGluR5. Katz M, et al. Nat Commun, 2019 Apr 23. PMID 31015396, Free PMC Article
    4. Glial Expression of the Caenorhabditis elegans Gene swip-10 Supports Glutamate Dependent Control of Extrasynaptic Dopamine Signaling. Hardaway JA, et al. J Neurosci, 2015 Jun 24. PMID 26109664, Free PMC Article
    5. Guanosine Prevents against Glutamatergic Excitotoxicity in C. elegans. da Silveira TL, et al. Neuroscience, 2019 Aug 21. PMID 31306683

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables L-glutamate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables L-glutamate transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glutamate:sodium symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables neutral L-amino acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables symporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-alpha-amino acid transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in L-glutamate transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neutral amino acid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell projection IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Excitatory amino acid transporter
    NP_001024393.1
    • Confirmed by transcript evidence
    NP_001024394.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      3496026..3499169
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001029222.4 → NP_001024393.1  Excitatory amino acid transporter [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024393.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P90798, Q10901, Q17920
      Conserved Domains (1) summary
      pfam00375
      Location:21 → 458
      SDF; Sodium:dicarboxylate symporter family

    2. NM_001029223.6 → NP_001024394.1  Excitatory amino acid transporter [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024394.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q10901
      Conserved Domains (1) summary
      pfam00375
      Location:10 → 447
      SDF; Sodium:dicarboxylate symporter family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q10901.2

    Gene LinkOut

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