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    nhl-3 B box-type domain-containing protein;RING-type domain-containing protein;Tripartite motif-containing protein 2 [ Caenorhabditis elegans ]

    Gene ID: 173452, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nhl-3
    Official Full Name
    B box-type domain-containing protein;RING-type domain-containing protein;Tripartite motif-containing protein 2
    Primary source
    WormBase:WBGene00003599
    Locus tag
    CELE_W04H10.3
    See related
    AllianceGenome:WB:WBGene00003599
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ubiquitin protein ligase activity. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in acute promyelocytic leukemia and skin cancer. Orthologous to human PML (PML nuclear body scaffold) and TRIM45 (tripartite motif containing 45). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See nhl-3 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    12
    Sequence:
    Chromosome: II; NC_003280.10 (595202..602120, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene DDE_3 domain-containing protein Neighboring gene Transposase Neighboring gene DNA topoisomerase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. C. elegans Brat homologs regulate PAR protein-dependent polarity and asymmetric cell division. Hyenne V, et al. Dev Biol, 2008 Sep 15. PMID 18652816
    2. nhl-2 Modulates microRNA activity in Caenorhabditis elegans. Hammell CM, et al. Cell, 2009 Mar 6. PMID 19269369, Free PMC Article
    3. Ubiquitin-mediated pathways in C. elegans. Kipreos ET. WormBook, 2005 Dec 1. PMID 18050424, Free PMC Article
    4. Transcriptional regulation. Okkema PG, et al. WormBook, 2005 Dec 23. PMID 18050428, Free PMC Article
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    B box-type domain-containing protein;RING-type domain-containing protein;Tripartite motif-containing protein 2
    NP_001040817.2
    • Confirmed by transcript evidence
    NP_001040818.2
    • Confirmed by transcript evidence
    NP_001303793.1
    • Confirmed by transcript evidence
    NP_001303794.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      595202..602120 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001047352.5 → NP_001040817.2  RING-type domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001040817.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2L0K3
      Conserved Domains (6) summary
      COG1196
      Location:164 → 310
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd05819
      Location:489 → 528
      NHL; NHL repeat [structural motif]
      cl18310
      Location:452 → 696
      NHL; NHL repeat unit of beta-propeller proteins
      cd16587
      Location:24 → 74
      RING-HC_TRIM32_C-VII; RING finger, HC subclass, found in tripartite motif-containing protein 32 (TRIM32) and similar proteins
      pfam00630
      Location:344 → 422
      Filamin; Filamin/ABP280 repeat
      cl00034
      Location:111 → 134
      Bbox_SF; B-box-type zinc finger superfamily

    2. NM_001047353.6 → NP_001040818.2  B box-type domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001040818.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      F8Y420
      Conserved Domains (5) summary
      smart00502
      Location:84 → 169
      BBC; B-Box C-terminal domain
      cd05819
      Location:390 → 429
      NHL; NHL repeat [structural motif]
      cl18310
      Location:353 → 597
      NHL; NHL repeat unit of beta-propeller proteins
      pfam00630
      Location:245 → 323
      Filamin; Filamin/ABP280 repeat
      cl00034
      Location:12 → 35
      Bbox_SF; B-box-type zinc finger superfamily

    3. NM_001316864.3 → NP_001303793.1  Tripartite motif-containing protein 2 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0M7RE93
      Conserved Domains (3) summary
      cd05819
      Location:237 → 276
      NHL; NHL repeat [structural motif]
      cl18310
      Location:200 → 444
      NHL; NHL repeat unit of beta-propeller proteins
      pfam00630
      Location:92 → 170
      Filamin; Filamin/ABP280 repeat

    4. NM_001316865.3 → NP_001303794.1  Tripartite motif-containing protein 2 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0M7RF55
      Conserved Domains (2) summary
      cd05819
      Location:40 → 80
      NHL; NHL repeat [structural motif]
      cl18310
      Location:9 → 153
      NHL; NHL repeat unit of beta-propeller proteins
    Nucleotide Protein
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