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    ttx-1 Homeobox protein ttx-1 [ Caenorhabditis elegans ]

    Gene ID: 180313, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ttx-1
    Official Full Name
    Homeobox protein ttx-1
    Primary source
    WormBase:WBGene00006652
    Locus tag
    CELE_Y113G7A.6
    See related
    AllianceGenome:WB:WBGene00006652
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables DNA-binding transcription factor activity and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including positive regulation of transcription by RNA polymerase II; regulation of plasma membrane bounded cell projection assembly; and thermosensory behavior. Located in nucleus. Is expressed in head neurons and pharyngeal cell. Human ortholog(s) of this gene implicated in panhypopituitarism and syndromic microphthalmia 5. Orthologous to several human genes including OTX1 (orthodenticle homeobox 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ttx-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    10
    Sequence:
    Chromosome: V; NC_003283.11 (20053719..20064176, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene CX domain-containing protein Neighboring gene Serpentine Receptor, class H Neighboring gene NADPH-dependent diflavin oxidoreductase 1 Neighboring gene ncRNA Neighboring gene 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase;m7GpppX diphosphatase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Modulation of Caenorhabditis elegans chemotaxis by cultivation and assay temperatures. Adachi R, et al. Neurosci Res, 2008 Mar. PMID 18192049
    2. Exposure to metals induces morphological and functional alteration of AFD neurons in nematode Caenorhabditis elegans. Xing X, et al. Environ Toxicol Pharmacol, 2009 Jul. PMID 21783989
    3. Thermotaxis in Caenorhabditis elegans analyzed by measuring responses to defined Thermal stimuli. Ryu WS, et al. J Neurosci, 2002 Jul 1. PMID 12097525, Free PMC Article
    4. Graphene oxide-induced neurotoxicity on neurotransmitters, AFD neurons and locomotive behavior in Caenorhabditis elegans. Kim M, et al. Neurotoxicology, 2020 Mar. PMID 31862286
    5. Step response analysis of thermotaxis in Caenorhabditis elegans. Zariwala HA, et al. J Neurosci, 2003 May 15. PMID 12764126, Free PMC Article

    See all (61) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in embryo development ending in birth or egg hatching IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of microvillus assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of non-motile cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in thermosensory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Homeobox protein ttx-1
    NP_001024212.1
    • Confirmed by transcript evidence
    NP_001024213.1
    • Partially confirmed by transcript evidence
    NP_001129914.1
    • Confirmed by transcript evidence
    NP_001317838.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      20053719..20064176 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001029042.5 → NP_001024213.1  Homeobox protein ttx-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024213.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9U2Y9
      Conserved Domains (1) summary
      pfam00046
      Location:150 → 203
      Homeobox; Homeobox domain

    2. NM_001330887.2 → NP_001317838.1  Homeobox protein ttx-1 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A168HA93
      Conserved Domains (1) summary
      pfam00046
      Location:191 → 244
      Homeobox; Homeobox domain

    3. NM_001029041.3 → NP_001024212.1  Homeobox protein ttx-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024212.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A168HA93, B5QSI6, Q95W16, Q95W17, Q95W18, Q9U2Y9, Q9U2Z0
      Conserved Domains (1) summary
      pfam00046
      Location:203 → 256
      Homeobox; Homeobox domain

    4. NM_001136442.4 → NP_001129914.1  Homeobox protein ttx-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001129914.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B5QSI6
      Conserved Domains (1) summary
      pfam00046
      Location:166 → 219
      Homeobox; Homeobox domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9U2Z0.2

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