swsn-4 SWI/SNF chromatin remodeling complex core catalytic subunit swsn-4 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: swsn-4
Official Full Name: SWI/SNF chromatin remodeling complex core catalytic subunit swsn-4
Primary source: WormBase:WBGene00004204
Locus tag: CELE_F01G4.1
See related: AllianceGenome:WB:WBGene00004204
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable DNA binding activity; chromatin binding activity; and nucleosome array spacer activity. Involved in gonad development. Predicted to be located in chromatin. Predicted to be active in nucleus. Is expressed in several structures, including hypodermis; intestine; nervous system; tail; and vulval cell. Used to study alcohol use disorder and cancer. Human ortholog(s) of this gene implicated in Coffin-Siris syndrome 4; Nicolaides-Baraitser syndrome; blepharophimosis-impaired intellectual development syndrome; carcinoma (multiple); and rhabdoid cancer. Orthologous to human SMARCA2 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2) and SMARCA4 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See swsn-4 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 8

Sequence:: Chromosome: IV; NC_003282.8 (11126024..11131162)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Loss of DAF-16/FOXO impairs binding of SWSN-4 specifically to promoters.
Title: DAF-16 employs the chromatin remodeller SWI/SNF to promote stress resistance and longevity.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F01G4.1 (e-PCR)
- UniSTS:307421

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP-dependent chromatin remodeler activity	IEA Inferred from Electronic Annotation more info
enables DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables chromatin binding	IBA Inferred from Biological aspect of Ancestor more info
enables helicase activity	IEA Inferred from Electronic Annotation more info
enables histone binding	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables nucleosome array spacer activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in chromatin organization	IEA Inferred from Electronic Annotation more info
involved_in gonad development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heterochromatin formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in chromatin	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: SWI/SNF chromatin remodeling complex core catalytic subunit swsn-4

NP_502082.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

11126024..11131162

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_069681.8 → NP_502082.1 SWI/SNF chromatin remodeling complex core catalytic subunit swsn-4 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_502082.1

Status: REVIEWED

UniProtKB/Swiss-Prot

G5EF53

Conserved Domains (8) summary

cd05516
Location:1181 → 1287

Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...

smart00592
Location:404 → 448

BRK; domain in transcription and CHROMO domain helicases

smart00573
Location:272 → 344

HSA; domain in helicases and associated with SANT domains

cd00046
Location:553 → 692

DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.

pfam00176
Location:536 → 824

SNF2_N; SNF2 family N-terminal domain

pfam00271
Location:850 → 964

Helicase_C; Helicase conserved C-terminal domain

pfam08880
Location:88 → 116

QLQ; QLQ

pfam14619
Location:1059 → 1131

SnAC; Snf2-ATP coupling, chromatin remodelling complex