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    cogc-3 Conserved oligomeric Golgi complex subunit 3;Conserved oligomeric Golgi complex subunit 3 C-terminal domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 171867, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cogc-3
    Official Full Name
    Conserved oligomeric Golgi complex subunit 3;Conserved oligomeric Golgi complex subunit 3 C-terminal domain-containing protein
    Primary source
    WormBase:WBGene00022121
    Locus tag
    CELE_Y71F9AM.4
    See related
    AllianceGenome:WB:WBGene00022121
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in gonad morphogenesis and regulation of cell migration. Located in Golgi apparatus and endoplasmic reticulum. Is expressed in intestine; pharynx; seam cell; and vulva. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type II. Orthologous to human COG3 (component of oligomeric golgi complex 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See cogc-3 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    14
    Sequence:
    Chromosome: I; NC_003279.8 (2931461..2947106)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Translocon-associated protein subunit alpha Neighboring gene NTF2-related export protein Neighboring gene ncRNA Neighboring gene Conserved secreted protein Neighboring gene Neuropeptide-Like Protein Neighboring gene ncRNA Neighboring gene Secreted protein Neighboring gene Neurexin-related protein bam-2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. C. elegans as a model system to study the function of the COG complex in animal development. Kubota Y, et al. Biol Chem, 2006 Aug. PMID 16895472
    2. Serum- and Glucocorticoid-Inducible Kinase-1 (SGK-1) Plays a Role in Membrane Trafficking in Caenorhabditis elegans. Zhu M, et al. PLoS One, 2015. PMID 26115433, Free PMC Article
    3. The conserved oligomeric Golgi complex acts in organ morphogenesis via glycosylation of an ADAM protease in C. elegans. Kubota Y, et al. Development, 2006 Jan. PMID 16354716
    4. RNA targets and specificity of Staufen, a double-stranded RNA-binding protein in Caenorhabditis elegans. LeGendre JB, et al. J Biol Chem, 2013 Jan 25. PMID 23195953, Free PMC Article
    5. A protein domain-based interactome network for C. elegans early embryogenesis. Boxem M, et al. Cell, 2008 Aug 8. PMID 18692475, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in Golgi organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in gonad morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intra-Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of Golgi transport complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cis-Golgi network IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Conserved oligomeric Golgi complex subunit 3;Conserved oligomeric Golgi complex subunit 3 C-terminal domain-containing protein
    NP_001021806.1
    • Confirmed by transcript evidence
    NP_001380050.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      2931461..2947106
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001026635.5 → NP_001021806.1  Conserved oligomeric Golgi complex subunit 3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021806.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q2V0X4, Q6AW08
      Conserved Domains (1) summary
      pfam04136
      Location:79 → 205
      Sec34; Sec34-like family

    2. NM_001393155.1 → NP_001380050.1  Conserved oligomeric Golgi complex subunit 3 C-terminal domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2L0S2
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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