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    let-526 ARID domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 3565337, updated on 9-Dec-2024

    Summary

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    Official Symbol
    let-526
    Official Full Name
    ARID domain-containing protein
    Primary source
    WormBase:WBGene00002717
    Locus tag
    CELE_C01G8.9
    See related
    AllianceGenome:WB:WBGene00002717
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable DNA binding activity. Predicted to contribute to nucleosome binding activity. Involved in gonad development; nematode larval development; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including excretory cell; gonad; intestine; tail precursor cell; and vulva. Used to study alcohol use disorder and cancer. Human ortholog(s) of this gene implicated in several diseases, including Coffin-Siris syndrome (multiple); breast cancer; carcinoma (multiple); gastrointestinal system cancer (multiple); and neuroblastoma. Orthologous to several human genes including ARID1A (AT-rich interaction domain 1A). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See let-526 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    15
    Sequence:
    Chromosome: I; NC_003279.8 (5300901..5317392, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Remorin_C domain-containing protein Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene DET1- and DDB1-associated protein 1 Neighboring gene OCIA domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Multiple functions of PBRM-1/Polybromo- and LET-526/Osa-containing chromatin remodeling complexes in C. elegans development. Shibata Y, et al. Dev Biol, 2012 Jan 15. PMID 22119053
    2. A Caenorhabditis elegans Model for Integrating the Functions of Neuropsychiatric Risk Genes Identifies Components Required for Normal Dendritic Morphology. Aguirre-Chen C, et al. G3 (Bethesda), 2020 May 4. PMID 32132169, Free PMC Article
    3. Metabolic effects of manganese in the nematode Caenorhabditis elegans through DAergic pathway and transcription factors activation. Gubert P, et al. Neurotoxicology, 2018 Jul. PMID 29673961
    4. High-throughput capturing and characterization of mutations in essential genes of Caenorhabditis elegans. Chu JS, et al. BMC Genomics, 2014 May 12. PMID 24884423, Free PMC Article
    5. Co-option of the piRNA pathway for germline-specific alternative splicing of C. elegans TOR. Barberán-Soler S, et al. Cell Rep, 2014 Sep 25. PMID 25220461

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MicroRNA let-7 expression is upregulated in response to notch protein activation.
      Title: Upregulation of the let-7 microRNA with precocious development in lin-12/Notch hypermorphic Caenorhabditis elegans mutants.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    contributes_to nucleosome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in gonad development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nematode larval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of SWI/SNF complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SWI/SNF complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of SWI/SNF complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    part_of SWI/SNF superfamily-type complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of brahma complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of nBAF complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ARID domain-containing protein
    NP_001293325.1
    • Confirmed by transcript evidence
    NP_001367394.1
    • Confirmed by transcript evidence
    NP_001368147.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      5300901..5317392 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001380177.1 → NP_001367394.1  ARID domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      P91019
      Conserved Domains (4) summary
      PHA03247
      Location:544 → 835
      PHA03247; large tegument protein UL36; Provisional
      PRK12323
      Location:545 → 660
      PRK12323; DNA polymerase III subunit gamma/tau
      cd16865
      Location:263 → 357
      ARID_ARID1A-like; ARID/BRIGHT DNA binding domain found in AT-rich interactive domain-containing proteins ARID1A, ARID1B and similar proteins
      pfam12031
      Location:1183 → 1454
      BAF250_C; SWI/SNF-like complex subunit BAF250/Osa

    2. NM_001306396.3 → NP_001293325.1  ARID domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293325.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X5M5M2
      Conserved Domains (4) summary
      PHA03247
      Location:598 → 889
      PHA03247; large tegument protein UL36; Provisional
      PRK12323
      Location:599 → 714
      PRK12323; DNA polymerase III subunit gamma/tau
      cd16865
      Location:317 → 411
      ARID_ARID1A-like; ARID/BRIGHT DNA binding domain found in AT-rich interactive domain-containing proteins ARID1A, ARID1B and similar proteins
      pfam12031
      Location:1237 → 1508
      BAF250_C; SWI/SNF-like complex subunit BAF250/Osa

    3. NM_001380175.2 → NP_001368147.1  ARID domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      J7SA49
      Conserved Domains (4) summary
      PHA03247
      Location:625 → 916
      PHA03247; large tegument protein UL36; Provisional
      PRK12323
      Location:626 → 741
      PRK12323; DNA polymerase III subunit gamma/tau
      cd16865
      Location:344 → 438
      ARID_ARID1A-like; ARID/BRIGHT DNA binding domain found in AT-rich interactive domain-containing proteins ARID1A, ARID1B and similar proteins
      pfam12031
      Location:1264 → 1535
      BAF250_C; SWI/SNF-like complex subunit BAF250/Osa

    RNA

    1. NR_131382.1 RNA Sequence

      Status: REVIEWED

    Nucleotide Protein
    Heading Accession and Version

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