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    Pafah1b2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 64189, updated on 10-Dec-2024

    Summary

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    Official Symbol
    Pafah1b2provided by RGD
    Official Full Name
    platelet-activating factor acetylhydrolase 1b, catalytic subunit 2provided by RGD
    Primary source
    RGD:620332
    See related
    EnsemblRapid:ENSRNOG00000057102 AllianceGenome:RGD:620332
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables 1-alkyl-2-acetylglycerophosphocholine esterase activity; identical protein binding activity; and platelet-activating factor acetyltransferase activity. Predicted to be involved in positive regulation of macroautophagy and spermatogenesis. Part of 1-alkyl-2-acetylglycerophosphocholine esterase complex. Human ortholog(s) of this gene implicated in lymphoma. Orthologous to human PAFAH1B2 (platelet activating factor acetylhydrolase 1b catalytic subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 343.2), Adrenal (RPKM 234.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pafah1b2 in Genome Data Viewer
    Location:
    8q22
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (55156778..55208800, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (46260069..46312073, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (50256969..50310043, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120094332 Neighboring gene transgelin Neighboring gene SID1 transmembrane family, member 2 Neighboring gene ribosomal protein S26, pseudogene 6 Neighboring gene uncharacterized LOC120094333 Neighboring gene SIK family kinase 3 Neighboring gene POU class 5 homeobox 1, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. MicroRNA-212-5p and its target PAFAH1B2 suppress vascular proliferation and contraction via the downregulation of RhoA. Kim GR, et al. PLoS One, 2021. PMID 33760887, Free PMC Article
    2. Anti-apoptotic actions of the platelet-activating factor acetylhydrolase I alpha2 catalytic subunit. Bonin F, et al. J Biol Chem, 2004 Dec 10. PMID 15456758
    3. Platelet-activating factor (PAF) acetylhydrolase activity, LIS1 expression, and seizures. Shmueli O, et al. J Neurosci Res, 1999 Jul 15. PMID 10398295
    4. Switching of platelet-activating factor acetylhydrolase catalytic subunits in developing rat brain. Manya H, et al. J Biol Chem, 1998 Jul 17. PMID 9660828
    5. Molecular cloning of cDNAs encoding alpha1, alpha2, and beta subunits of rat brain platelet-activating factor acetylhydrolase. Watanabe M, et al. Biochim Biophys Acta, 1998 Jan 2. PMID 9459487

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MicroRNA-212-5p and its target PAFAH1B2 suppress vascular proliferation and contraction via the downregulation of RhoA.
      Title: MicroRNA-212-5p and its target PAFAH1B2 suppress vascular proliferation and contraction via the downregulation of RhoA.
    2. the PAF receptor-independent death pathway is regulated by PAF-AH I alpha2
      Title: Anti-apoptotic actions of the platelet-activating factor acetylhydrolase I alpha2 catalytic subunit.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC93124

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 1-alkyl-2-acetylglycerophosphocholine esterase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 1-alkyl-2-acetylglycerophosphocholine esterase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables platelet-activating factor acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables platelet-activating factor acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables platelet-activating factor acetyltransferase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein heterodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein-containing complex binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of macroautophagy ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within spermatogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spermatogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spermatogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of 1-alkyl-2-acetylglycerophosphocholine esterase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of 1-alkyl-2-acetylglycerophosphocholine esterase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in fibrillar center IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in fibrillar center ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    platelet-activating factor acetylhydrolase IB subunit alpha2
    Names
    PAF acetylhydrolase 30 kDa subunit
    PAF-AH 30 kDa subunit
    PAF-AH alpha 2
    PAF-AH subunit beta
    PAFAH subunit beta
    platelet-activating factor acetylhydrolase IB subunit beta
    platelet-activating factor acetylhydrolase alpha 2 subunit (PAF-AH alpha 2)
    NP_071782.1
    XP_006243020.1
    XP_038938009.1
    XP_038938010.1
    XP_063122144.1
    XP_063122145.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022387.3 → NP_071782.1  platelet-activating factor acetylhydrolase IB subunit alpha2

      See identical proteins and their annotated locations for NP_071782.1

      Status: PROVISIONAL

      Source sequence(s)
      BC081714
      UniProtKB/Swiss-Prot
      O35264
      UniProtKB/TrEMBL
      A0A8L2R003, A6J468
      Related
      ENSRNOP00000068672.3, ENSRNOT00000082508.3
      Conserved Domains (1) summary
      cd01820
      Location:8 → 217
      PAF_acetylesterase_like; PAF_acetylhydrolase (PAF-AH)_like subfamily of SGNH-hydrolases. Platelet-activating factor (PAF) and PAF-AH are key players in inflammation and in atherosclerosis. PAF-AH is a calcium independent phospholipase A2 which exhibits strong substrate ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      55156778..55208800 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006242958.5 → XP_006243020.1  platelet-activating factor acetylhydrolase IB subunit alpha2 isoform X1

      See identical proteins and their annotated locations for XP_006243020.1

      UniProtKB/Swiss-Prot
      O35264
      UniProtKB/TrEMBL
      A0A8L2R003, A6J468
      Conserved Domains (1) summary
      cd01820
      Location:8 → 217
      PAF_acetylesterase_like; PAF_acetylhydrolase (PAF-AH)_like subfamily of SGNH-hydrolases. Platelet-activating factor (PAF) and PAF-AH are key players in inflammation and in atherosclerosis. PAF-AH is a calcium independent phospholipase A2 which exhibits strong substrate ...

    2. XM_039082082.2 → XP_038938010.1  platelet-activating factor acetylhydrolase IB subunit alpha2 isoform X1

      UniProtKB/Swiss-Prot
      O35264
      UniProtKB/TrEMBL
      A0A8L2R003, A6J468
      Conserved Domains (1) summary
      cd01820
      Location:8 → 217
      PAF_acetylesterase_like; PAF_acetylhydrolase (PAF-AH)_like subfamily of SGNH-hydrolases. Platelet-activating factor (PAF) and PAF-AH are key players in inflammation and in atherosclerosis. PAF-AH is a calcium independent phospholipase A2 which exhibits strong substrate ...

    3. XM_063266075.1 → XP_063122145.1  platelet-activating factor acetylhydrolase IB subunit alpha2 isoform X1

      UniProtKB/Swiss-Prot
      O35264
      UniProtKB/TrEMBL
      A0A8L2R003, A6J468

    4. XM_039082081.2 → XP_038938009.1  platelet-activating factor acetylhydrolase IB subunit alpha2 isoform X1

      UniProtKB/Swiss-Prot
      O35264
      UniProtKB/TrEMBL
      A0A8L2R003, A6J468
      Conserved Domains (1) summary
      cd01820
      Location:8 → 217
      PAF_acetylesterase_like; PAF_acetylhydrolase (PAF-AH)_like subfamily of SGNH-hydrolases. Platelet-activating factor (PAF) and PAF-AH are key players in inflammation and in atherosclerosis. PAF-AH is a calcium independent phospholipase A2 which exhibits strong substrate ...

    5. XM_063266074.1 → XP_063122144.1  platelet-activating factor acetylhydrolase IB subunit alpha2 isoform X1

      UniProtKB/Swiss-Prot
      O35264
      UniProtKB/TrEMBL
      A0A8L2R003, A6J468
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O35264.1 GenPept UniProtKB/Swiss-Prot:O35264

    Gene LinkOut

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