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    Kcnk1 potassium two pore domain channel subfamily K member 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 59324, updated on 9-Dec-2024

    Summary

    Official Symbol
    Kcnk1provided by RGD
    Official Full Name
    potassium two pore domain channel subfamily K member 1provided by RGD
    Primary source
    RGD:621447
    See related
    EnsemblRapid:ENSRNOG00000019937 AllianceGenome:RGD:621447
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Twik
    Summary
    Enables potassium ion leak channel activity. Involved in potassium ion transmembrane transport and response to nicotine. Located in apical plasma membrane and brush border membrane. Orthologous to human KCNK1 (potassium two pore domain channel subfamily K member 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 140.4), Kidney (RPKM 78.6) and 2 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Kcnk1 in Genome Data Viewer
    Location:
    19q12
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (70856985..70895053)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (53959411..53997726)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (58823836..58862926)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene pecanex 2 Neighboring gene uncharacterized LOC120098634 Neighboring gene mitogen-activated protein kinase kinase kinase 21 Neighboring gene uncharacterized LOC134483661 Neighboring gene solute carrier family 35, member F3 Neighboring gene LIM domain-containing protein A-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding  
    enables identical protein binding  
    enables inward rectifier potassium channel activity  
    enables ligand-gated channel activity  
    enables ligand-gated channel activity  
    enables potassium channel activity  
    enables potassium channel activity  
    enables potassium ion leak channel activity  
    enables potassium ion leak channel activity PubMed 
    enables potassium ion leak channel activity  
    enables potassium ion leak channel activity  
    enables protein heterodimerization activity  
    enables protein heterodimerization activity  
    enables sodium channel activity PubMed 
    enables sodium channel activity  
    enables sodium channel activity  
    enables voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential  
    NOT enables voltage-gated potassium channel activity  
    Process Evidence Code Pubs
    involved_in cellular response to acidic pH PubMed 
    involved_in chloride transmembrane transport  
    involved_in chloride transmembrane transport  
    involved_in glutamate secretion  
    involved_in glutamate secretion  
    involved_in potassium ion transmembrane transport  
    involved_in potassium ion transmembrane transport PubMed 
    involved_in potassium ion transmembrane transport  
    involved_in potassium ion transmembrane transport  
    involved_in regulation of postsynaptic membrane potential  
    involved_in regulation of resting membrane potential  
    involved_in regulation of resting membrane potential  
    involved_in response to nicotine PubMed 
    involved_in sodium ion transmembrane transport  
    involved_in sodium ion transmembrane transport  
    Component Evidence Code Pubs
    located_in apical plasma membrane PubMed 
    located_in brush border membrane PubMed 
    located_in dendrite  
    located_in endosome  
    located_in intracellular membrane-bounded organelle  
    part_of inward rectifier potassium channel complex  
    located_in membrane  
    located_in membrane  
    located_in perikaryon  
    is_active_in plasma membrane  
    located_in plasma membrane PubMed 
    located_in plasma membrane  
    located_in plasma membrane  
    part_of potassium channel complex  
    part_of potassium channel complex  
    located_in recycling endosome  
    located_in synaptic membrane  

    General protein information

    Preferred Names
    potassium channel subfamily K member 1
    Names
    inward rectifying potassium channel protein TWIK-1
    potassium channel K2P1
    potassium channel, subfamily K, member 1
    potassium channel, two pore domain subfamily K, member 1
    putative potassium channel TWIK
    rTWIK

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021688.3NP_067720.1  potassium channel subfamily K member 1

      See identical proteins and their annotated locations for NP_067720.1

      Status: VALIDATED

      Source sequence(s)
      BC061807, JAXUCZ010000019
      UniProtKB/Swiss-Prot
      Q9Z2T2
      UniProtKB/TrEMBL
      A6KJ44
      Related
      ENSRNOP00000027058.3, ENSRNOT00000027058.7
      Conserved Domains (1) summary
      pfam07885
      Location:101157
      Ion_trans_2; Ion channel

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      70856985..70895053
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063278268.1XP_063134338.1  potassium channel subfamily K member 1 isoform X3

    2. XM_039097960.2XP_038953888.1  potassium channel subfamily K member 1 isoform X1

      Conserved Domains (1) summary
      pfam07885
      Location:139214
      Ion_trans_2; Ion channel
    3. XM_006255820.5XP_006255882.1  potassium channel subfamily K member 1 isoform X2

      Conserved Domains (1) summary
      pfam07885
      Location:126202
      Ion_trans_2; Ion channel
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