spr-3 Suppressor of presenilin protein 3 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: spr-3
Official Full Name: Suppressor of presenilin protein 3
Primary source: WormBase:WBGene00005008
Locus tag: CELE_C07A12.5
See related: AllianceGenome:WB:WBGene00005008
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable DNA binding activity and metal ion binding activity. Predicted to be involved in regulation of gene expression. Predicted to be active in nucleus. Used to study Alzheimer's disease. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See spr-3 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 5

Sequence:: Chromosome: X; NC_003284.9 (4514093..4516895)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In wild-type worms, overexpression of spr-4 suppresses excitation and extends lifespan. REST, SPR-3, SPR-4 and reduced excitation activate the longevity-associated transcription factors FOXO1 and DAF-16 in mammals and worms, respectively. These findings reveal a conserved mechanism of ageing that is mediated by neural circuit activity and regulated by REST.
Title: Regulation of lifespan by neural excitation and REST.
Data report the cloning and characterization of spr-3 and spr-4, which encode large basic zinc-finger proteins which act as transcriptional repressors for sel-12 [spr-3 and spr-4].
Title: Two suppressors of sel-12 encode C2H2 zinc-finger proteins that regulate presenilin transcription in Caenorhabditis elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C07A12.5 (e-PCR)
- UniSTS:308982

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Suppressor of presenilin protein 3

NP_001024367.1

Confirmed by transcript evidence

NP_001359833.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

4514093..4516895

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001373281.4 → NP_001359833.1 Suppressor of presenilin protein 3 [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (1) summary

sd00017
Location:22 → 42

ZF_C2H2; C2H2 Zn finger [structural motif]
NM_001029196.5 → NP_001024367.1 Suppressor of presenilin protein 3 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001024367.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q17768, Q7JP33