cyp51 cytochrome P450, family 51 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: cyp51provided by ZNC
Official Full Name: cytochrome P450, family 51provided by ZNC
Primary source: ZFIN:ZDB-GENE-040625-2
See related: Ensembl:ENSDARG00000042641 AllianceGenome:ZFIN:ZDB-GENE-040625-2
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: LDM; wu:fb66a09
Summary: Enables sterol 14-demethylase activity. Acts upstream of or within response to yeast. Predicted to be located in endoplasmic reticulum membrane. Is expressed in several structures, including epidermis; head; liver; pleuroperitoneal region; and primordial germ cell. Orthologous to human CYP51A1 (cytochrome P450 family 51 subfamily A member 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 19

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	19	NC_007130.7 (598657..617175, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	19	NC_007130.6 (598848..617366, complement)

Chromosome 19 - NC_007130.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Markers

fb61b10.x1 (e-PCR)
- UniSTS:190869

fb61b10.x1 (e-PCR)
- UniSTS:190870

fb66a09.x1 (e-PCR)
- UniSTS:187322

AI545923 (e-PCR)
- UniSTS:206277

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables heme binding	IEA Inferred from Electronic Annotation more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables monooxygenase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IBA Inferred from Biological aspect of Ancestor more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	IEA Inferred from Electronic Annotation more info
enables sterol 14-demethylase activity	IDA Inferred from Direct Assay more info	PubMed
enables sterol 14-demethylase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cholesterol biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in cholesterol biosynthetic process via 24,25-dihydrolanosterol	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cholesterol metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to yeast	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within steroid biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within steroid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within sterol biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: lanosterol 14-alpha demethylase

Names: 14-alpha demethylase; cytochrome P450 family member 51; cytochrome P450, subfamily 51; sterol 14-alpha demethylase

NP_001001730.2

EC 1.14.14.154

XP_068071214.1

EC 1.14.14.154

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

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These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.