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    cyp27a2 cytochrome P450 family 27 subfamily A member 2 [ Danio rerio (zebrafish) ]

    Gene ID: 558239, updated on 9-Dec-2024

    Summary

    Official Symbol
    cyp27a2provided by ZNC
    Official Full Name
    cytochrome P450 family 27 subfamily A member 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-120215-110
    See related
    Ensembl:ENSDARG00000073764 AllianceGenome:ZFIN:ZDB-GENE-120215-110
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    si:ch211-113j14.1
    Summary
    Predicted to enable cholesterol 26-hydroxylase activity and vitamin D3 25-hydroxylase activity. Predicted to be involved in calcitriol biosynthetic process from calciol and cholesterol metabolic process. Predicted to be active in mitochondrion. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See cyp27a2 in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (9467602..9529120, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (9235345..9293632, complement)

    Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene kalirin RhoGEF kinase b Neighboring gene serine/threonine-protein kinase pim-1 Neighboring gene mitogen-activated protein kinase kinase kinase 2 Neighboring gene cytochrome P450, family 27, subfamily C, polypeptide 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    General gene information

    Markers

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables cholesterol 26-hydroxylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
    Inferred from Electronic Annotation
    more info
     
    enables vitamin D3 25-hydroxylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in calcitriol biosynthetic process from calciol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cholesterol metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    sterol 26-hydroxylase, mitochondrial

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007117.7 Reference GRCz11 Primary Assembly

      Range
      9467602..9529120 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_681430.8XP_686522.4  sterol 26-hydroxylase, mitochondrial

      UniProtKB/TrEMBL
      A0A8N7USW5, E7F3G8
      Related
      ENSDARP00000099662.3, ENSDART00000109113.4
      Conserved Domains (1) summary
      pfam00067
      Location:108569
      p450; Cytochrome P450