cyp24a1 cytochrome P450, family 24, subfamily A, polypeptide 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: cyp24a1provided by ZNC
Official Full Name: cytochrome P450, family 24, subfamily A, polypeptide 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-060825-1
See related: Ensembl:ENSDARG00000103277 AllianceGenome:ZFIN:ZDB-GENE-060825-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cyp24a1l
Summary: Predicted to enable 1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity; 25-hydroxycholecalciferol-24-hydroxylase activity; and vitamin D 25-hydroxylase activity. Predicted to be involved in response to vitamin D and vitamin D catabolic process. Is expressed in liver. Human ortholog(s) of this gene implicated in colorectal adenoma; gastrointestinal system cancer (multiple); hypercalcemia; lung cancer (multiple); and ulcerative colitis. Orthologous to human CYP24A1 (cytochrome P450 family 24 subfamily A member 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 6

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	6	NC_007117.7 (55852274..55864687, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	6	NC_007117.6 (55869080..55881493, complement)

Chromosome 6 - NC_007117.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables 1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 25-hydroxycholecalciferol-24-hydroxylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables heme binding	IEA Inferred from Electronic Annotation more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables monooxygenase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	IEA Inferred from Electronic Annotation more info
enables vitamin D 25-hydroxylase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in response to vitamin D	IBA Inferred from Biological aspect of Ancestor more info
involved_in vitamin D catabolic process	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial

Names: cytochrome P450, family 24, subfamily A, polypeptide 1, like

NP_001082927.1

EC 1.14.15.16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

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These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.