hopx HOP homeobox [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: hopxprovided by ZNC
Official Full Name: HOP homeoboxprovided by ZNC
Primary source: ZFIN:ZDB-GENE-031016-2
See related: Ensembl:ENSDARG00000089368 AllianceGenome:ZFIN:ZDB-GENE-031016-2
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: hop
Summary: Predicted to enable DNA binding activity. Acts upstream of or within heart development. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Is expressed in hatching gland; heart; sensory system; and solid lens vesicle. Orthologous to human HOPX (HOP homeobox). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 14

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	14	NC_007125.7 (1170968..1178363)
105	previous assembly	GRCz10 (GCF_000002035.5)	14	NC_007125.6 (1152704..1160099)

Chromosome 14 - NC_007125.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within heart development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: homeodomain-only protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_198209.2 → NP_937852.1 homeodomain-only protein

See identical proteins and their annotated locations for NP_937852.1

Status: PROVISIONAL

Source sequence(s)

BC096856

UniProtKB/Swiss-Prot

A8E5B8, Q4V9K4, Q8AYB8

Related

ENSDARP00000112208.1, ENSDART00000125203.3

Conserved Domains (1) summary

cd00086
Location:12 → 66

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.