gja10b gap junction protein alpha 10 b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: gja10bprovided by ZNC
Official Full Name: gap junction protein alpha 10 bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040310-6
See related: Ensembl:ENSDARG00000034930 AllianceGenome:ZFIN:ZDB-GENE-040310-6
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cx52.6
Summary: Enables gap junction hemi-channel activity. Predicted to act upstream of or within cell communication. Located in gap junction. Is expressed in brain; heart; and retina. Orthologous to human GJA10 (gap junction protein alpha 10). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 20

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	20	NC_007131.7 (23960360..23964334)
105	previous assembly	GRCz10 (GCF_000002035.5)	20	NC_007131.6 (24061439..24063066)

Chromosome 20 - NC_007131.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cx52.6 is alternatively spliced in the retina, resulting in an additional isoform, designated as Cx53.4, which differs from the originally described Cx52.6 only by the final C-terminal peptide (12 vs. 4 aa). Further protein sequence alignments revealed that Cx53.4 represents the counterpart of alternatively spliced mouse Cx57 and human Cx62.
Title: An Alternative Splice Variant of Zebrafish Cx52.6 is Expressed in Retinal Horizontal Cells.
This study showed that Cx52.6 promoter activity was present in horizontal 4 cells and in the ventral quadrant of the retina also in horizontal 1 cells.
Title: Specific connectivity between photoreceptors and horizontal cells in the zebrafish retina.
Cx52.6 contributes to horizontal cell hemichannel currents at the first visual synapse
Title: Physiological and molecular characterization of connexin hemichannels in zebrafish retinal horizontal cells.
These results offer the first in vivo demonstration of the HC-specific activities of the Cx52.6 and Cx55.5 promoters. Furthermore, these data provide the first proof at the protein level for retinal HC-specific connexins in the zebrafish.
Title: Retinal horizontal cell-specific promoter activity and protein expression of zebrafish connexin 52.6 and connexin 55.5.
cx52.6 is expressed in horizontal cells in the inner nuclear layer of the retina
Title: Molecular cloning and functional expression of zfCx52.6: a novel connexin with hemichannel-forming properties expressed in horizontal cells of the zebrafish retina.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables gap junction channel activity	IDA Inferred from Direct Assay more info	PubMed
enables gap junction hemi-channel activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell communication	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
part_of connexin complex	IEA Inferred from Electronic Annotation more info
located_in gap junction	IDA Inferred from Direct Assay more info	PubMed
located_in gap junction	IEA Inferred from Electronic Annotation more info
located_in gap junction	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: gap junction alpha-10 protein

Names: connexin 52.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_212819.1 → NP_997984.1 gap junction alpha-10 protein

See identical proteins and their annotated locations for NP_997984.1

Status: PROVISIONAL

Source sequence(s)

AF465750

UniProtKB/TrEMBL

E7F3P4, Q8JHW1

Conserved Domains (3) summary

smart00037
Location:44 → 76

CNX; Connexin homologues

smart01089
Location:166 → 232

Connexin_CCC; Gap junction channel protein cysteine-rich domain

pfam00029
Location:3 → 234

Connexin; Connexin