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    ivns1abpa influenza virus NS1A binding protein a [ Danio rerio (zebrafish) ]

    Gene ID: 387591, updated on 9-Dec-2024

    Summary

    Official Symbol
    ivns1abpaprovided by ZNC
    Official Full Name
    influenza virus NS1A binding protein aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-031222-2
    See related
    Ensembl:ENSDARG00000031100 AllianceGenome:ZFIN:ZDB-GENE-031222-2
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    cb1052; fj23g11; ivns1abp; wu:fj23g11
    Summary
    Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be located in cytoskeleton and nucleus. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Is expressed in several structures, including ectoderm; pronephric duct; pronephric mesoderm; sensory system; and solid lens vesicle. Human ortholog(s) of this gene implicated in immunodeficiency 70. Orthologous to human IVNS1ABP (influenza virus NS1A binding protein). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    NEW
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    Genomic context

    See ivns1abpa in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (34326872..34341185)
    105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (34423993..34438306)

    Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene actin related protein 2/3 complex, subunit 5B Neighboring gene hemicentin 1 Neighboring gene SWT1 RNA endoribonuclease homolog Neighboring gene tRNA methyltransferase 1-like Neighboring gene niban apoptosis regulator 1a

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    General gene information

    Markers

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ubiquitin-like ligase-substrate adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    part_of Cul3-RING ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    influenza virus NS1A-binding protein homolog A
    Names
    NS1-BP homolog A
    NS1-binding protein homolog A
    wz2894

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199279.2NP_954973.2  influenza virus NS1A-binding protein homolog A

      See identical proteins and their annotated locations for NP_954973.2

      Status: VALIDATED

      Source sequence(s)
      AW202903, BC066513, BX957305, CK028387, DN860974
      UniProtKB/Swiss-Prot
      Q5RG82, Q6NYP3, Q7ZUZ3
      UniProtKB/TrEMBL
      A0A8M9PH64
      Related
      ENSDARP00000061658.4, ENSDART00000061659.5
      Conserved Domains (2) summary
      sd00038
      Location:502545
      Kelch; KELCH repeat [structural motif]
      cl28614
      Location:23634
      BTB; Broad-Complex, Tramtrack and Bric a brac

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007131.7 Reference GRCz11 Primary Assembly

      Range
      34326872..34341185
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)