cpt1a2b carnitine palmitoyltransferase 1A2b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: cpt1a2bprovided by ZNC
Official Full Name: carnitine palmitoyltransferase 1A2bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-050417-155
See related: Ensembl:ENSDARG00000037943 AllianceGenome:ZFIN:ZDB-GENE-050417-155
Gene type: protein coding
RefSeq status: MODEL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cpt1cb; zgc:112484; si:dkey-16p21.4
Summary: Predicted to enable carnitine O-palmitoyltransferase activity. Predicted to be involved in fatty acid beta-oxidation. Predicted to act upstream of or within fatty acid metabolic process. Predicted to be located in membrane. Is expressed in EVL; periderm; and polster. Human ortholog(s) of this gene implicated in carnitine palmitoyltransferase I deficiency; hereditary spastic paraplegia 73; and lipid metabolism disorder. Orthologous to human CPT1A (carnitine palmitoyltransferase 1A) and CPT1C (carnitine palmitoyltransferase 1C). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: chromosome: 3

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	3	NC_007114.7 (32225309..32290053, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	3	NC_007114.6 (32096679..32158374, complement)

Chromosome 3 - NC_007114.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables carnitine O-palmitoyltransferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in fatty acid beta-oxidation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within fatty acid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: carnitine O-palmitoyltransferase 1, liver isoform; carnitine palmitoyltransferase 1A2b

Names: carnitine palmitoyltransferase 1Cb

XP_005164116.1

EC 2.3.1.21

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007114.7 Reference GRCz11 Primary Assembly

Range

32225309..32290053 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005164059.5 → XP_005164116.1 carnitine O-palmitoyltransferase 1, liver isoform

UniProtKB/TrEMBL

A0A8M2BBH8, A0A8M9PFB6, E7EYD4

Related

ENSDARP00000124943.1, ENSDART00000148763.3

Conserved Domains (2) summary

pfam00755
Location:171 → 761

Carn_acyltransf; Choline/Carnitine o-acyltransferase

pfam16484
Location:1 → 46

CPT_N; Carnitine O-palmitoyltransferase N-terminus

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001017668.1: Suppressed sequence

Description

NM_001017668.1: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from frog (X.tr): cpt1a (GeneID:100135089).