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    lsy-27 Zinc finger protein lsy-27 [ Caenorhabditis elegans ]

    Gene ID: 180149, updated on 9-Dec-2024

    Summary

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    Official Symbol
    lsy-27
    Official Full Name
    Zinc finger protein lsy-27
    Primary source
    WormBase:WBGene00009834
    Locus tag
    CELE_F47H4.1
    See related
    AllianceGenome:WB:WBGene00009834
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Involved in neuron differentiation and regulation of DNA-templated transcription. Predicted to be active in nucleus. Is expressed in several structures, including ASE; germ line; oocyte; somatic nervous system; and tail neurons. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See lsy-27 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    3
    Sequence:
    Chromosome: V; NC_003283.11 (17348665..17350193, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene F-box domain-containing protein Neighboring gene F-box domain-containing protein Neighboring gene Skp1-related protein Neighboring gene DUF38 domain-containing protein Neighboring gene DUF38 domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A left/right asymmetric neuronal differentiation program is controlled by the Caenorhabditis elegans lsy-27 zinc-finger transcription factor. Zhang F, et al. Genetics, 2011 Jul. PMID 21555395, Free PMC Article
    2. Genetic screens for Caenorhabditis elegans mutants defective in left/right asymmetric neuronal fate specification. Sarin S, et al. Genetics, 2007 Aug. PMID 17717195, Free PMC Article
    3. Extensive rewiring and complex evolutionary dynamics in a C. elegans multiparameter transcription factor network. Reece-Hoyes JS, et al. Mol Cell, 2013 Jul 11. PMID 23791784, Free PMC Article
    4. Transcriptional regulation. Okkema PG, et al. WormBook, 2005 Dec 23. PMID 18050428, Free PMC Article
    5. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Zinc finger protein lsy-27
    NP_001256739.1
    • Confirmed by transcript evidence
    NP_001256740.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      17348665..17350193 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001269810.2 → NP_001256739.1  Zinc finger protein lsy-27 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256739.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      H9G332, O45526
      Conserved Domains (2) summary
      COG5236
      Location:22 → 122
      COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
      sd00017
      Location:27 → 48
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. NM_001269811.3 → NP_001256740.1  Zinc finger protein lsy-27 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256740.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H9G332
      Conserved Domains (2) summary
      sd00019
      Location:8 → 29
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12756
      Location:8 → 53
      zf-C2H2_2; C2H2 type zinc-finger (2 copies)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O45526.1

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