U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    ctsf cathepsin F [ Danio rerio (zebrafish) ]

    Gene ID: 565588, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    ctsfprovided by ZNC
    Official Full Name
    cathepsin Fprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-9831
    See related
    Ensembl:ENSDARG00000063095 AllianceGenome:ZFIN:ZDB-GENE-030131-9831
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    cb420; sb:cb420; zgc:153093
    Summary
    Predicted to enable cysteine-type endopeptidase activity. Predicted to be involved in proteolysis involved in protein catabolic process. Predicted to act upstream of or within proteolysis. Predicted to be active in extracellular space and lysosome. Is expressed in mesoderm; nervous system; neural tube; solid lens vesicle; and ventral mesenchyme. Human ortholog(s) of this gene implicated in neuronal ceroid lipofuscinosis 13. Orthologous to human CTSF (cathepsin F). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See ctsf in Genome Data Viewer
    Location:
    chromosome: 14
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (7140997..7164646)
    105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (6834549..6858237)

    Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene si:ch73-43g23.1 Neighboring gene tRNA phosphotransferase 1 Neighboring gene storkhead box 2b Neighboring gene trafficking protein particle complex subunit 11

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Comparative genomic of the teleost cathepsin B and H and involvement in bacterial induced immunity of miiuy croaker. Che R, et al. Fish Shellfish Immunol, 2014 Dec. PMID 25181651
    2. Phylogenetic relationships and gene expression pattern of three different cathepsin L (Ctsl) isoforms in zebrafish: Ctsla is the putative yolk processing enzyme. Tingaud-Sequeira A, et al. Gene, 2007 Jan 15. PMID 17027199
    3. Zebrafish Chromosome 14 Gene Differential Expression in the fmr1 (h u2787) Model of Fragile X Syndrome. Barthelson K, et al. Front Genet, 2021. PMID 34135935, Free PMC Article
    4. Expressed sequence tag analysis of zebrafish eye tissues for NEIBank. Vihtelic TS, et al. Mol Vis, 2005 Dec 13. PMID 16379021
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • MGC153093

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables cysteine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cysteine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis involved in protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    cathepsin F
    NP_001071036.1
    XP_005157210.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001077568.1 → NP_001071036.1  cathepsin F precursor

      See identical proteins and their annotated locations for NP_001071036.1

      Status: PROVISIONAL

      Source sequence(s)
      BC124243
      UniProtKB/TrEMBL
      Q08CH0
      Related
      ENSDARP00000112297.1, ENSDART00000129898.3
      Conserved Domains (4) summary
      PTZ00203
      Location:143 → 472
      PTZ00203; cathepsin L protease; Provisional
      smart00043
      Location:34 → 144
      CY; Cystatin-like domain
      smart00848
      Location:175 → 231
      Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)
      pfam00112
      Location:262 → 471
      Peptidase_C1; Papain family cysteine protease

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007125.7 Reference GRCz11 Primary Assembly

      Range
      7140997..7164646
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005157153.5 → XP_005157210.1  cathepsin F isoform X1

      UniProtKB/TrEMBL
      A0A8M9QKM5, F1RE14
      Related
      ENSDARP00000132041.1, ENSDART00000170994.2
      Conserved Domains (3) summary
      smart00043
      Location:34 → 144
      CY; Cystatin-like domain
      smart00848
      Location:175 → 231
      Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)
      pfam00112
      Location:262 → 471
      Peptidase_C1; Papain family cysteine protease
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.