sae1 SUMO1 activating enzyme subunit 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: sae1provided by ZNC
Official Full Name: SUMO1 activating enzyme subunit 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-040625-21
See related: Ensembl:ENSDARG00000010487 AllianceGenome:ZFIN:ZDB-GENE-040625-21
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: sae2a; uble1a; fa28b04; zgc:86633; wu:fa28b04
Summary: Predicted to enable SUMO activating enzyme activity. Acts upstream of or within definitive hemopoiesis; hematopoietic stem cell homeostasis; and protein sumoylation. Predicted to be located in nucleus. Predicted to be part of SUMO activating enzyme complex. Predicted to be active in cytoplasm. Is expressed in brain. Orthologous to human SAE1 (SUMO1 activating enzyme subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 15

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	15	NC_007126.7 (23722627..23739104)
105	previous assembly	GRCz10 (GCF_000002035.5)	15	NC_007126.6 (23787362..23803836)

Chromosome 15 - NC_007126.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

sae1 is essential for the maintenance of hematopoietic stem/progenitor cells during fetal hematopoiesis in zebrafish.
Title: SUMO1-activating enzyme subunit 1 is essential for the survival of hematopoietic stem/progenitor cells in zebrafish.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

fa28b04.s1 (e-PCR)
- UniSTS:202499

fj30b03.y1 (e-PCR)
- UniSTS:199006

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables SUMO activating enzyme activity	IBA Inferred from Biological aspect of Ancestor more info
contributes_to SUMO activating enzyme activity	ISS Inferred from Sequence or Structural Similarity more info
enables ligase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin-like modifier activating enzyme activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within definitive hemopoiesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hematopoietic stem cell homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein modification by small protein conjugation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein modification process	IEA Inferred from Electronic Annotation more info
involved_in protein sumoylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein sumoylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein sumoylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein sumoylation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of SUMO activating enzyme complex	IBA Inferred from Biological aspect of Ancestor more info
part_of SUMO activating enzyme complex	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: SUMO-activating enzyme subunit 1

Names: SUMO1 activating enzyme subunit 2a; ubiquitin-like 1 (sentrin) activating enzyme E1A; ubiquitin-like 1-activating enzyme E1A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001002058.1 → NP_001002058.1 SUMO-activating enzyme subunit 1

See identical proteins and their annotated locations for NP_001002058.1

Status: PROVISIONAL

Source sequence(s)

BC071328

UniProtKB/Swiss-Prot

Q6IQS6

Related

ENSDARP00000016138.8, ENSDART00000011447.9

Conserved Domains (2) summary

cd01492
Location:17 → 343

Aos1_SUMO; Ubiquitin activating enzyme (E1) subunit Aos1. Aos1 is part of the heterodimeric activating enzyme (E1), specific for the SUMO family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to ...

pfam00899
Location:20 → 167

ThiF; ThiF family

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007126.7 Reference GRCz11 Primary Assembly

Range

23722627..23739104

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021481377.2 → XP_021337052.1 SUMO-activating enzyme subunit 1 isoform X1

UniProtKB/TrEMBL

A0A8M9Q099

Conserved Domains (1) summary

cd01492
Location:17 → 170

Aos1_SUMO; Ubiquitin activating enzyme (E1) subunit Aos1. Aos1 is part of the heterodimeric activating enzyme (E1), specific for the SUMO family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to ...