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    pacsin3 protein kinase C and casein kinase substrate in neurons 3 [ Danio rerio (zebrafish) ]

    Gene ID: 393964, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pacsin3provided by ZNC
    Official Full Name
    protein kinase C and casein kinase substrate in neurons 3provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-984
    See related
    Ensembl:ENSDARG00000099339 AllianceGenome:ZFIN:ZDB-GENE-040426-984
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    Pacsin1; fa11d03; fj67e09; zgc:56324; wu:fa11d03; wu:fj67e09; wu:fq16a06
    Summary
    Predicted to enable phospholipid binding activity. Acts upstream of or within notochord cell differentiation and notochord formation. Located in plasma membrane. Is expressed in several structures, including central nervous system; intestinal bulb primordium; musculature system; pleuroperitoneal region; and sensory system. Orthologous to human PACSIN3 (protein kinase C and casein kinase substrate in neurons 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See pacsin3 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (54222169..54308069)
    105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (53952489..54038417)

    Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene casein kinase 1, gamma 1 Neighboring gene uncharacterized LOC137496221 Neighboring gene uncharacterized LOC137496220 Neighboring gene Fas (tnfrsf6)-associated via death domain Neighboring gene anoctamin 1, calcium activated chloride channel a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Structural requirements for PACSIN/Syndapin operation during zebrafish embryonic notochord development. Edeling MA, et al. PLoS One, 2009 Dec 3. PMID 19997509, Free PMC Article
    2. Pacsin2 is required for endocytosis in the zebrafish pronephric tubule. Morgan J, et al. Biol Open, 2022 Jun 15. PMID 35616009, Free PMC Article
    3. Novel Genes Critical for Hypoxic Preconditioning in Zebrafish Are Regulators of Insulin and Glucose Metabolism. Manchenkov T, et al. G3 (Bethesda), 2015 Apr 3. PMID 25840431, Free PMC Article
    4. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC56324

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within notochord cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within notochord formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein kinase C and casein kinase substrate in neurons protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200989.1 → NP_957283.1  protein kinase C and casein kinase substrate in neurons protein 3

      See identical proteins and their annotated locations for NP_957283.1

      Status: PROVISIONAL

      Source sequence(s)
      BC046073
      UniProtKB/TrEMBL
      A0A8M9QGQ8, A0A8N1Z331, Q7ZUY8
      Related
      ENSDARP00000131278.1, ENSDART00000165201.3
      Conserved Domains (1) summary
      cd07681
      Location:16 → 273
      F-BAR_PACSIN3; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Protein kinase C and Casein kinase Substrate in Neurons 3 (PACSIN3)

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007118.7 Reference GRCz11 Primary Assembly

      Range
      54222169..54308069
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005166593.4 → XP_005166650.1  protein kinase C and casein kinase substrate in neurons protein 3 isoform X1

      See identical proteins and their annotated locations for XP_005166650.1

      UniProtKB/TrEMBL
      A0A8M2BE23, A0A8M3B1H5, B0R118
      Conserved Domains (2) summary
      cd07681
      Location:16 → 273
      F-BAR_PACSIN3; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Protein kinase C and Casein kinase Substrate in Neurons 3 (PACSIN3)
      cl17036
      Location:376 → 431
      SH3; Src Homology 3 domain superfamily

    2. XM_005166594.4 → XP_005166651.1  protein kinase C and casein kinase substrate in neurons protein 3 isoform X1

      See identical proteins and their annotated locations for XP_005166651.1

      UniProtKB/TrEMBL
      A0A8M2BE23, A0A8M3B1H5, B0R118
      Related
      ENSDARP00000138125.2, ENSDART00000158518.3
      Conserved Domains (2) summary
      cd07681
      Location:16 → 273
      F-BAR_PACSIN3; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Protein kinase C and Casein kinase Substrate in Neurons 3 (PACSIN3)
      cl17036
      Location:376 → 431
      SH3; Src Homology 3 domain superfamily

    3. XM_005166595.5 → XP_005166652.1  protein kinase C and casein kinase substrate in neurons protein 3 isoform X1

      See identical proteins and their annotated locations for XP_005166652.1

      UniProtKB/TrEMBL
      A0A8M2BE23, A0A8M3B1H5, B0R118
      Conserved Domains (2) summary
      cd07681
      Location:16 → 273
      F-BAR_PACSIN3; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Protein kinase C and Casein kinase Substrate in Neurons 3 (PACSIN3)
      cl17036
      Location:376 → 431
      SH3; Src Homology 3 domain superfamily
    Nucleotide Protein
    Heading Accession and Version

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