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    cul1b cullin 1b [ Danio rerio (zebrafish) ]

    Gene ID: 406816, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cul1bprovided by ZNC
    Official Full Name
    cullin 1bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-2887
    See related
    Ensembl:ENSDARG00000007691 AllianceGenome:ZFIN:ZDB-GENE-040426-2887
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    cul1; zgc:55483; wu:fi43h07; wu:fj43a08; zgc:111899
    Summary
    Predicted to enable protein-macromolecule adaptor activity and ubiquitin protein ligase binding activity. Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process and protein ubiquitination. Predicted to act upstream of or within neutrophil chemotaxis and non-canonical NF-kappaB signal transduction. Predicted to be part of SCF ubiquitin ligase complex. Orthologous to human CUL1 (cullin 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See cul1b in Genome Data Viewer
    Location:
    chromosome: 24
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 24 NC_007135.7 (17364588..17400134, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 24 NC_007135.6 (17220326..17255710, complement)

    Chromosome 24 - NC_007135.7Genomic Context describing neighboring genes Neighboring gene protein disulfide isomerase family A, member 4 Neighboring gene enhancer of zeste 2 polycomb repressive complex 2 subunit Neighboring gene uncharacterized LOC137489229 Neighboring gene si:dkey-117j14.8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. MicroRNA-223 Suppresses the Canonical NF-κB Pathway in Basal Keratinocytes to Dampen Neutrophilic Inflammation. Zhou W, et al. Cell Rep, 2018 Feb 13. PMID 29444433, Free PMC Article
    2. Comparative analysis of single-cell transcriptomics in human and Zebrafish oocytes. Can H, et al. BMC Genomics, 2020 Jul 8. PMID 32640983, Free PMC Article
    3. Identification and Expression Analysis of the Complete Family of Zebrafish pkd Genes. England SJ, et al. Front Cell Dev Biol, 2017. PMID 28271061, Free PMC Article
    4. Knockout of mafba Causes Inner-Ear Developmental Defects in Zebrafish via the Impairment of Proliferation and Differentiation of Ionocyte Progenitor Cells. Chen X, et al. Biomedicines, 2021 Nov 16. PMID 34829928, Free PMC Article
    5. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables protein-macromolecule adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within non-canonical NF-kappaB signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cullin-RING ubiquitin ligase complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cullin-1b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_213495.1 → NP_998660.1  cullin-1b

      See identical proteins and their annotated locations for NP_998660.1

      Status: PROVISIONAL

      Source sequence(s)
      BC048370
      UniProtKB/TrEMBL
      Q802D4
      Related
      ENSDARP00000002286.6, ENSDART00000024691.9
      Conserved Domains (3) summary
      smart00182
      Location:453 → 588
      CULLIN; Cullin
      smart00884
      Location:701 → 768
      Cullin_Nedd8; Cullin protein neddylation domain
      pfam00888
      Location:22 → 660
      Cullin; Cullin family

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007135.7 Reference GRCz11 Primary Assembly

      Range
      17364588..17400134 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021470126.2 → XP_021325801.1  cullin-1b isoform X1

      UniProtKB/TrEMBL
      A0A8M9PTY1
      Conserved Domains (2) summary
      smart00884
      Location:701 → 748
      Cullin_Nedd8; Cullin protein neddylation domain
      pfam00888
      Location:22 → 660
      Cullin; Cullin family
    Nucleotide Protein Strain
    Heading Accession and Version

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