gna11b guanine nucleotide binding protein (G protein), alpha 11b (Gq class) [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: gna11bprovided by ZNC
Official Full Name: guanine nucleotide binding protein (G protein), alpha 11b (Gq class)provided by ZNC
Primary source: ZFIN:ZDB-GENE-041121-9
See related: Ensembl:ENSDARG00000053326 AllianceGenome:ZFIN:ZDB-GENE-041121-9
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: wu:fb12d06; zgc:101761
Summary: Predicted to enable several functions, including G-protein beta/gamma-subunit complex binding activity; GTPase activator activity; and GTPase activity. Predicted to be involved in G protein-coupled receptor signaling pathway; entrainment of circadian clock; and phototransduction, visible light. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in membrane and photoreceptor outer segment. Predicted to be part of heterotrimeric G-protein complex. Predicted to be active in cytoplasm. Is expressed in barbel; brain; gill; lip; and sensory system. Human ortholog(s) of this gene implicated in autosomal dominant hypocalcemia 2 and familial hypocalciuric hypercalcemia 2. Orthologous to human GNA11 (G protein subunit alpha 11). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 2

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	2	NC_007113.7 (52469820..52550135, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	2	NC_007113.6 (52876107..52956422, complement)

Chromosome 2 - NC_007113.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fb12d06.x1 (e-PCR)
- UniSTS:202866

fc80c01.x1 (e-PCR)
- UniSTS:188299

fk84e01.x1 (e-PCR)
- UniSTS:201612

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables G protein-coupled receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor binding	IEA Inferred from Electronic Annotation more info
enables G-protein beta/gamma-subunit complex binding	IBA Inferred from Biological aspect of Ancestor more info
enables G-protein beta/gamma-subunit complex binding	IEA Inferred from Electronic Annotation more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables guanyl nucleotide binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G protein-coupled acetylcholine receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in entrainment of circadian clock	ISS Inferred from Sequence or Structural Similarity more info
involved_in phototransduction, visible light	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
part_of heterotrimeric G-protein complex	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in photoreceptor outer segment	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: guanine nucleotide-binding protein subunit alpha-11b

Names: G11-1; Galpha 11a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001007773.1 → NP_001007774.1 guanine nucleotide-binding protein subunit alpha-11b

See identical proteins and their annotated locations for NP_001007774.1

Status: PROVISIONAL

Source sequence(s)

BC085433

UniProtKB/TrEMBL

B2GP20, F6P189, Q5RKP9

Related

ENSDARP00000044410.4, ENSDART00000044411.6

Conserved Domains (2) summary

cd00066
Location:40 → 353

G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)

smart00275
Location:19 → 357

G_alpha; G protein alpha subunit