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    kmt5aa lysine methyltransferase 5Aa [ Danio rerio (zebrafish) ]

    Gene ID: 751629, updated on 9-Dec-2024

    Summary

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    Official Symbol
    kmt5aaprovided by ZNC
    Official Full Name
    lysine methyltransferase 5Aaprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060825-37
    See related
    Ensembl:ENSDARG00000105231 AllianceGenome:ZFIN:ZDB-GENE-060825-37
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    set8a; setd8a; wu:fj33f02; zgc:153719
    Summary
    Predicted to enable histone H4K20 methyltransferase activity. Acts upstream of or within dorsal/ventral pattern formation and positive regulation of gene expression. Predicted to be located in chromosome. Predicted to be active in nucleus and polytene chromosome. Is expressed in blastoderm; blastodisc; brain; and intermediate cell mass of mesoderm. Orthologous to human KMT5A (lysine methyltransferase 5A). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See kmt5aa in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 10 NC_007121.7 (44363180..44372381)
    105 previous assembly GRCz10 (GCF_000002035.5) 10 NC_007121.6 (44446488..44455689)

    Chromosome 10 - NC_007121.7Genomic Context describing neighboring genes Neighboring gene zinc finger, SWIM-type containing 6 Neighboring gene cyclin dependent kinase 2 associated protein 1 Neighboring gene strawberry notch homolog 1 (Drosophila) Neighboring gene small nuclear ribonucleoprotein 35 (U11/U12) Neighboring gene CAP-GLY domain containing linker protein 1b Neighboring gene density-regulated protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Histone H4 Lys 20 monomethylation by histone methylase SET8 mediates Wnt target gene activation. Li Z, et al. Proc Natl Acad Sci U S A, 2011 Feb 22. PMID 21282610, Free PMC Article
    2. Genome-wide survey and developmental expression mapping of zebrafish SET domain-containing genes. Sun XJ, et al. PLoS One, 2008 Jan 30. PMID 18231586, Free PMC Article
    3. A network of epigenetic regulators guides developmental haematopoiesis in vivo. Huang HT, et al. Nat Cell Biol, 2013 Dec. PMID 24240475, Free PMC Article
    4. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC153719

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables histone H4K20 methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone H4K20 methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4K20 monomethyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone methyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within dorsal/ventral pattern formation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within dorsal/ventral pattern formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of gene expression IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA damage response, signal transduction by p53 class mediator IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in polytene chromosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    N-lysine methyltransferase KMT5A-A
    Names
    N-lysine methyltransferase SETD8-A
    PR/SET domain containing protein 8a
    SET domain containing (lysine methyltransferase) 8a
    SET domain-containing 8
    SET domain-containing protein 8-A
    histone-lysine N-methyltransferase KMT5A-A
    histone-lysine N-methyltransferase SETD8-A
    lysine-specific methylase 5A-A
    NP_001038814.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001045349.2 → NP_001038814.2  N-lysine methyltransferase KMT5A-A

      See identical proteins and their annotated locations for NP_001038814.2

      Status: PROVISIONAL

      Source sequence(s)
      DQ343297
      UniProtKB/Swiss-Prot
      Q071E0, Q0P3X5
      Related
      ENSDARP00000140543.1, ENSDART00000161744.3
      Conserved Domains (1) summary
      smart00317
      Location:212 → 334
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007121.7 Reference GRCz11 Primary Assembly

      Range
      44363180..44372381
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q071E0.1 GenPept UniProtKB/Swiss-Prot:Q071E0

    Gene LinkOut

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