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    arhgef4 Rho guanine nucleotide exchange factor (GEF) 4 [ Danio rerio (zebrafish) ]

    Gene ID: 559017, updated on 9-Dec-2024

    Summary

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    Official Symbol
    arhgef4provided by ZNC
    Official Full Name
    Rho guanine nucleotide exchange factor (GEF) 4provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-070912-575
    See related
    Ensembl:ENSDARG00000012914 AllianceGenome:ZFIN:ZDB-GENE-070912-575
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    si:dkey-74f15.3
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to act upstream of or within intracellular signal transduction. Orthologous to human ARHGEF4 (Rho guanine nucleotide exchange factor 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See arhgef4 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (16198735..16359016, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (16530145..16690426, complement)

    Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene selenoprotein J Neighboring gene SH3-domain GRB2-like endophilin B1b Neighboring gene APC membrane recruitment protein 3 Neighboring gene ATR serine/threonine kinase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Constitutive RAC activation is not sufficient to initiate melanocyte neoplasia but accelerates malignant progression. Dalton LE, et al. J Invest Dermatol, 2013 Jun. PMID 23337888
    2. RhoA GEF Mcf2lb regulates rosette integrity during collective cell migration. Olson HM, et al. Development, 2024 Jan 1. PMID 38165177, Free PMC Article
    3. The guanine nucleotide exchange factor Net1 facilitates the specification of dorsal cell fates in zebrafish embryos by promoting maternal β-catenin activation. Wei S, et al. Cell Res, 2017 Feb. PMID 27910850, Free PMC Article
    4. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
    5. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    rho guanine nucleotide exchange factor 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007113.7 Reference GRCz11 Primary Assembly

      Range
      16198735..16359016 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009298440.4 → XP_009296715.1  rho guanine nucleotide exchange factor 4 isoform X2

      UniProtKB/TrEMBL
      A0A8M3APK8, A0A8M9PKC3, E7FAH9
      Related
      ENSDARP00000057215.4, ENSDART00000057216.8
      Conserved Domains (5) summary
      pfam09528
      Location:392 → 854
      Ehrlichia_rpt; Ehrlichia tandem repeat (Ehrlichia_rpt)
      cd11973
      Location:2546 → 2617
      SH3_ASEF; Src homology 3 domain of APC-Stimulated guanine nucleotide Exchange Factor
      cd01224
      Location:2843 → 2982
      PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain
      pfam00169
      Location:2871 → 2972
      PH; PH domain
      pfam00621
      Location:2659 → 2838
      RhoGEF; RhoGEF domain

    2. XM_009298443.4 → XP_009296718.1  rho guanine nucleotide exchange factor 4 isoform X5

      UniProtKB/TrEMBL
      A0A8M3B060, A0A8M9PKC3
      Conserved Domains (5) summary
      pfam09528
      Location:392 → 854
      Ehrlichia_rpt; Ehrlichia tandem repeat (Ehrlichia_rpt)
      cd11973
      Location:2446 → 2517
      SH3_ASEF; Src homology 3 domain of APC-Stimulated guanine nucleotide Exchange Factor
      cd01224
      Location:2743 → 2882
      PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain
      pfam00169
      Location:2771 → 2872
      PH; PH domain
      pfam00621
      Location:2559 → 2738
      RhoGEF; RhoGEF domain

    3. XM_009298437.4 → XP_009296712.1  rho guanine nucleotide exchange factor 4 isoform X1

      UniProtKB/TrEMBL
      A0A8M3B055, A0A8M9PKC3
      Conserved Domains (5) summary
      pfam09528
      Location:392 → 854
      Ehrlichia_rpt; Ehrlichia tandem repeat (Ehrlichia_rpt)
      cd11973
      Location:2546 → 2617
      SH3_ASEF; Src homology 3 domain of APC-Stimulated guanine nucleotide Exchange Factor
      cd01224
      Location:2843 → 2982
      PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain
      pfam00169
      Location:2871 → 2972
      PH; PH domain
      pfam00621
      Location:2659 → 2838
      RhoGEF; RhoGEF domain

    4. XM_009298441.4 → XP_009296716.1  rho guanine nucleotide exchange factor 4 isoform X4

      UniProtKB/TrEMBL
      A0A8M3B7L7, A0A8M9PKC3
      Conserved Domains (5) summary
      pfam09528
      Location:335 → 797
      Ehrlichia_rpt; Ehrlichia tandem repeat (Ehrlichia_rpt)
      cd11973
      Location:2489 → 2560
      SH3_ASEF; Src homology 3 domain of APC-Stimulated guanine nucleotide Exchange Factor
      cd01224
      Location:2786 → 2925
      PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain
      pfam00169
      Location:2814 → 2915
      PH; PH domain
      pfam00621
      Location:2602 → 2781
      RhoGEF; RhoGEF domain

    5. XM_009298442.4 → XP_009296717.1  rho guanine nucleotide exchange factor 4 isoform X3

      UniProtKB/TrEMBL
      A0A8M3AQ48, A0A8M9PKC3
      Conserved Domains (5) summary
      pfam09528
      Location:335 → 797
      Ehrlichia_rpt; Ehrlichia tandem repeat (Ehrlichia_rpt)
      cd11973
      Location:2489 → 2560
      SH3_ASEF; Src homology 3 domain of APC-Stimulated guanine nucleotide Exchange Factor
      cd01224
      Location:2786 → 2925
      PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain
      pfam00169
      Location:2814 → 2915
      PH; PH domain
      pfam00621
      Location:2602 → 2781
      RhoGEF; RhoGEF domain

    6. XM_682312.9 → XP_687404.3  rho guanine nucleotide exchange factor 4 isoform X6

      UniProtKB/TrEMBL
      A0A8N7USX6
      Related
      ENSDARP00000121185.2, ENSDART00000133708.4
      Conserved Domains (4) summary
      cd11973
      Location:104 → 175
      SH3_ASEF; Src homology 3 domain of APC-Stimulated guanine nucleotide Exchange Factor
      cd01224
      Location:401 → 540
      PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain
      pfam00169
      Location:429 → 530
      PH; PH domain
      pfam00621
      Location:217 → 396
      RhoGEF; RhoGEF domain

    7. XM_068213747.1 → XP_068069848.1  rho guanine nucleotide exchange factor 4 isoform X7

    Nucleotide Protein Strain
    Heading Accession and Version

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