ndor1 NADPH dependent diflavin oxidoreductase 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ndor1provided by ZNC
Official Full Name: NADPH dependent diflavin oxidoreductase 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-1555
See related: Ensembl:ENSDARG00000007429 AllianceGenome:ZFIN:ZDB-GENE-040426-1555
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:66159; wu:fc41f01
Summary: Predicted to enable several functions, including nucleotide binding activity; oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor; and oxidoreductase activity, acting on iron-sulfur proteins as donors, NAD or NADP as acceptor. Predicted to be involved in iron-sulfur cluster assembly. Predicted to be located in perinuclear region of cytoplasm. Predicted to be active in cytosol. Orthologous to human NDOR1 (NADPH dependent diflavin oxidoreductase 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 5

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	5	NC_007116.7 (32489837..32499063)
105	previous assembly	GRCz10 (GCF_000002035.5)	5	NC_007116.6 (31889697..31898784)

Chromosome 5 - NC_007116.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fj57a08.x1 (e-PCR)
- UniSTS:199588

fc41f01.x1 (e-PCR)
- UniSTS:188146

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables FMN binding	IBA Inferred from Biological aspect of Ancestor more info
enables FMN binding	IEA Inferred from Electronic Annotation more info
enables NADP binding	IEA Inferred from Electronic Annotation more info
enables NADPH-hemoprotein reductase activity	IEA Inferred from Electronic Annotation more info
enables electron transfer activity	ISS Inferred from Sequence or Structural Similarity more info
enables flavin adenine dinucleotide binding	IBA Inferred from Biological aspect of Ancestor more info
enables flavin adenine dinucleotide binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IBA Inferred from Biological aspect of Ancestor more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor	ISS Inferred from Sequence or Structural Similarity more info
enables oxidoreductase activity, acting on iron-sulfur proteins as donors, NAD or NADP as acceptor	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on iron-sulfur proteins as donors, NAD or NADP as acceptor	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in iron-sulfur cluster assembly	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: NADPH-dependent diflavin oxidoreductase 1

NP_956942.1

EC 1.6.-.-

XP_009299730.1

EC 1.6.-.-

XP_068077224.1

EC 1.6.-.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_200648.1 → NP_956942.1 NADPH-dependent diflavin oxidoreductase 1

See identical proteins and their annotated locations for NP_956942.1

Status: PROVISIONAL

Source sequence(s)

BC057471

UniProtKB/Swiss-Prot

Q5RL12, Q6PFP6

Related

ENSDARP00000156852.1, ENSDART00000191839.1

Conserved Domains (3) summary

COG0369
Location:5 → 594

CysJ; Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]

pfam00258
Location:8 → 145

Flavodoxin_1; Flavodoxin

cl06868
Location:214 → 594

FNR_like; Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport ...

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007116.7 Reference GRCz11 Primary Assembly

Range

32489837..32499063

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_009301455.3 → XP_009299730.1 NADPH-dependent diflavin oxidoreductase 1 isoform X1

UniProtKB/TrEMBL

A0A8M3ASF5, F1R9Y7

Conserved Domains (3) summary

COG0369
Location:5 → 594

CysJ; Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]

pfam00258
Location:8 → 145

Flavodoxin_1; Flavodoxin

cl06868
Location:214 → 594

FNR_like; Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport ...
XM_068221123.1 → XP_068077224.1 NADPH-dependent diflavin oxidoreductase 1 isoform X2