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    atp6v1h ATPase H+ transporting V1 subunit H [ Danio rerio (zebrafish) ]

    Gene ID: 286779, updated on 9-Dec-2024

    Summary

    Official Symbol
    atp6v1hprovided by ZNC
    Official Full Name
    ATPase H+ transporting V1 subunit Hprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-021219-2
    See related
    Ensembl:ENSDARG00000006370 AllianceGenome:ZFIN:ZDB-GENE-021219-2
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    chunp6890
    Summary
    Predicted to enable proton-transporting ATPase activity, rotational mechanism. Involved in eye pigmentation and positive regulation of neural retina development. Acts upstream of or within several processes, including bone development; bone mineralization; and retina development in camera-type eye. Predicted to be part of vacuolar proton-transporting V-type ATPase, V1 domain. Is expressed in several structures, including digestive system; gonad; integument; nervous system; and trigeminal placode. Used to study osteoporosis. Orthologous to human ATP6V1H (ATPase H+ transporting V1 subunit H). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See atp6v1h in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (30786760..30846873)
    105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (30803227..30863340)

    Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene transcription elongation factor A (SII), 1 Neighboring gene regulator of G protein signaling 20 Neighboring gene opioid receptor, kappa 1 Neighboring gene charged multivesicular body protein 5a

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    Pathways from PubChem

    General protein information

    Preferred Names
    V-type proton ATPase subunit H
    Names
    ATPase, H+ transporting, lysosomal V1 subunit H
    un-named hi923
    unm hi923
    NP_001278637.1
    NP_775377.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001291708.1NP_001278637.1  V-type proton ATPase subunit H isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1).
      Source sequence(s)
      EH445185, EH460143, EH549298, EH552114, EH570419
      UniProtKB/TrEMBL
      A0A8M1P5K1, B0R0V8
      Related
      ENSDARP00000113453.1, ENSDART00000145681.2
      Conserved Domains (1) summary
      cd00256
      Location:14461
      VATPase_H; regulatory vacuolar ATP synthase subunit H (Vma13p); activation component of the peripheral V1 complex of V-ATPase, a heteromultimeric enzyme which uses ATP to actively transport protons into organelles and extracellular compartments. The topology is ...
    2. NM_173270.3NP_775377.2  V-type proton ATPase subunit H isoform 2

      See identical proteins and their annotated locations for NP_775377.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame alternate exon in the coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1.
      Source sequence(s)
      EH460143, EH549298, EH552114, EH570419
      UniProtKB/TrEMBL
      Q6IQG5, Q6PC35
      Related
      ENSDARP00000024886.6, ENSDART00000019029.8
      Conserved Domains (1) summary
      cd00256
      Location:14443
      VATPase_H; VATPase_H, regulatory vacuolar ATP synthase subunit H (Vma13p); activation component of the peripheral V1 complex of V-ATPase, a heteromultimeric enzyme which uses ATP to actively transport protons into organelles and extracellular compartments. The ...

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007113.7 Reference GRCz11 Primary Assembly

      Range
      30786760..30846873
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)