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    pacc1 proton activated chloride channel 1 [ Danio rerio (zebrafish) ]

    Gene ID: 393429, updated on 4-Jan-2025

    Summary

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    Official Symbol
    pacc1provided by ZNC
    Official Full Name
    proton activated chloride channel 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-1173
    See related
    Ensembl:ENSDARG00000012271 AllianceGenome:ZFIN:ZDB-GENE-040426-1173
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    PAC; fPAC; tmem206; zgc:63579
    Summary
    Enables pH-gated chloride channel activity. Involved in chloride transport. Predicted to be located in plasma membrane. Predicted to be part of chloride channel complex. Orthologous to human PACC1 (proton activated chloride channel 1). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    human mouse all
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    Genomic context

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    See pacc1 in Genome Data Viewer
    Location:
    chromosome: 17
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (45378908..45386823, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (45395656..45403571, complement)

    Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene calpain 3a, (p94) Neighboring gene zinc finger protein 106a Neighboring gene neudesin neurotrophic factor Neighboring gene T cell activation RhoGTPase activating protein a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. PAC, an evolutionarily conserved membrane protein, is a proton-activated chloride channel. Yang J, et al. Science, 2019 Apr 26. PMID 31023925, Free PMC Article
    2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC63579

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables chloride channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pH-gated chloride channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chloride transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within chloride transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of chloride channel complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    proton-activated chloride channel
    Names
    transmembrane protein 206

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001291762.1 → NP_001278691.1  proton-activated chloride channel

      Status: VALIDATED

      Source sequence(s)
      BX322589
      UniProtKB/Swiss-Prot
      Q7SY31
      UniProtKB/TrEMBL
      A0A8M1P0Q6, X1WG42
      Related
      ENSDARP00000129197.2, ENSDART00000156002.3
      Conserved Domains (1) summary
      pfam15122
      Location:56 → 350
      TMEM206; TMEM206 protein family

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007128.7 Reference GRCz11 Primary Assembly

      Range
      45378908..45386823 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_200457.1: Suppressed sequence

      Description
      NM_200457.1: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7SY31.1 GenPept UniProtKB/Swiss-Prot:Q7SY31

    Gene LinkOut

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