mafba MAF bZIP transcription factor Ba [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: mafbaprovided by ZNC
Official Full Name: MAF bZIP transcription factor Baprovided by ZNC
Primary source: ZFIN:ZDB-GENE-980526-515
See related: Ensembl:ENSDARG00000017121 AllianceGenome:ZFIN:ZDB-GENE-980526-515
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: kr; val; krml; mafb; kreisler; wu:fc22d11; wu:fj82a09
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including hindbrain development; pronephric glomerulus development; and retinal rod cell development. Predicted to be active in nucleus. Is expressed in several structures, including hindbrain neural keel; nervous system; neural plate; renal system; and vein. Human ortholog(s) of this gene implicated in Duane retraction syndrome and multicentric carpotarsal osteolysis syndrome. Orthologous to human MAFB (MAF bZIP transcription factor B). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 23

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	23	NC_007134.7 (3405665..3409140, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	23	NC_007134.6 (3462555..3466030, complement)

Chromosome 23 - NC_007134.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mafba and Mafbb regulate microglial colonization of zebrafish brain via controlling chemotaxis receptor expression.
Title: Mafba and Mafbb regulate microglial colonization of zebrafish brain via controlling chemotaxis receptor expression.
Vegfc signaling increases mafba expression to control downstream transcription
Title: mafba is a downstream transcriptional effector of Vegfc signaling essential for embryonic lymphangiogenesis in zebrafish.

Submit: New GeneRIF Correction

General gene information

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Markers

fj82a09.x1 (e-PCR)
- UniSTS:200012

fa04g11.r1 (e-PCR)
- UniSTS:189531

val (e-PCR)
- UniSTS:187045

fc22d11.x1 (e-PCR)
- UniSTS:187817

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within abducens nucleus development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within anterior/posterior pattern specification	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic pattern specification	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within ionocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lymphangiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within pronephric glomerulus development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within retinal rod cell development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within rhombomere 5 development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within rhombomere 6 development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within rhombomere boundary formation	IMP Inferred from Mutant Phenotype more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: transcription factor MafB

Names: maf-B; transcription factor Val; v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog Ba; v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B; valentino

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131015.3 → NP_571090.2 transcription factor MafB

Status: VALIDATED

Source sequence(s)

CABZ01028915

UniProtKB/Swiss-Prot

O73679, Q98UK5

UniProtKB/TrEMBL

A0A2U3TVD3, A0A8M1PB55

Related

ENSDARP00000018087.6, ENSDART00000002309.8

Conserved Domains (2) summary

cd14718
Location:306 → 375

bZIP_Maf_large; Basic leucine zipper (bZIP) domain of large musculoaponeurotic fibrosarcoma (Maf) proteins: a DNA-binding and dimerization domain

pfam08383
Location:122 → 157

Maf_N; Maf N-terminal region