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    rsph4a radial spoke head component 4A [ Danio rerio (zebrafish) ]

    Gene ID: 100148286, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rsph4aprovided by ZNC
    Official Full Name
    radial spoke head component 4Aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-7437
    See related
    Ensembl:ENSDARG00000067606 AllianceGenome:ZFIN:ZDB-GENE-030131-7437
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    rshl3; rsph6a; wu:fj17d05
    Summary
    Predicted to be involved in axoneme assembly and cilium movement. Predicted to act upstream of or within cilium assembly and cilium movement involved in cell motility. Predicted to be located in cilium; cytoplasm; and cytoskeleton. Predicted to be part of radial spoke. Predicted to be active in axoneme. Is expressed in midbrain; otic placode; pronephric duct; and spinal cord neural rod. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 11. Orthologous to several human genes including RSPH4A (radial spoke head component 4A). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See rsph4a in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (61919224..61930917)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (61256479..61268123)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene interferon-induced protein with tetratricopeptide repeats 5 Neighboring gene symplekin Neighboring gene N-ethylmaleimide-sensitive factor attachment protein, alpha a Neighboring gene zinc finger BED-type containing 4-like 2 Neighboring gene zinc finger protein 541

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Novel roles for the radial spoke head protein 9 in neural and neurosensory cilia. Sedykh I, et al. Sci Rep, 2016 Sep 30. PMID 27687975, Free PMC Article
    2. Radial spoke proteins regulate otolith formation during early zebrafish development. Han X, et al. FASEB J, 2018 Jul. PMID 29475374
    3. Systematic discovery of novel ciliary genes through functional genomics in the zebrafish. Choksi SP, et al. Development, 2014 Sep. PMID 25139857, Free PMC Article
    4. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. rsph4a is essential for ciliary motility and otolith formation during early zebrafish development.
      Title: Radial spoke proteins regulate otolith formation during early zebrafish development.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    involved_in axoneme assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cilium assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cilium movement IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cilium movement involved in cell motility IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in axoneme IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cilium IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of radial spoke IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    radial spoke head protein 4 homolog A
    Names
    radial spoke head 4 homolog A
    radial spoke head 6 homolog A
    radial spokehead-like 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      61919224..61930917
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001923735.7 → XP_001923770.1  radial spoke head protein 4 homolog A

      See identical proteins and their annotated locations for XP_001923770.1

      UniProtKB/TrEMBL
      A0A8M1QHY3, A2CET1
      Related
      ENSDARP00000088110.4, ENSDART00000097340.5
      Conserved Domains (1) summary
      pfam04712
      Location:18 → 503
      Radial_spoke; Radial spokehead-like protein
    Nucleotide Protein Strain
    Heading Accession and Version

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