lipg lipase, endothelial [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: lipgprovided by ZNC
Official Full Name: lipase, endothelialprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-699
See related: Ensembl:ENSDARG00000031044 AllianceGenome:ZFIN:ZDB-GENE-040426-699
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:55345
Summary: Predicted to enable lipoprotein lipase activity and phospholipase A1 activity. Predicted to be involved in several processes, including cholesterol homeostasis; high-density lipoprotein particle remodeling; and triglyceride catabolic process. Predicted to act upstream of or within lipid catabolic process. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in myotome; nervous system; neural tube; and notochord. Human ortholog(s) of this gene implicated in cardiovascular system disease; cerebral infarction; coronary artery disease; and myocardial infarction. Orthologous to human LIPG (lipase G, endothelial type). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 8

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	8	NC_007119.7 (32376936..32386005, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	8	NC_007119.6 (32367704..32376773, complement)

Chromosome 8 - NC_007119.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables carboxylic ester hydrolase activity	IEA Inferred from Electronic Annotation more info
enables heparin binding	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables lipase activity	IEA Inferred from Electronic Annotation more info
enables lipoprotein lipase activity	IBA Inferred from Biological aspect of Ancestor more info
enables lipoprotein lipase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phospholipase A1 activity	IBA Inferred from Biological aspect of Ancestor more info
enables triacylglycerol lipase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cholesterol homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in fatty acid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in high-density lipoprotein particle remodeling	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within lipid catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in triglyceride catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: endothelial lipase

NP_956422.1

EC 3.1.1.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_200128.1 → NP_956422.1 endothelial lipase precursor

See identical proteins and their annotated locations for NP_956422.1

Status: PROVISIONAL

Source sequence(s)

BC044146

UniProtKB/TrEMBL

Q803Y3

Related

ENSDARP00000089620.3, ENSDART00000098850.5

Conserved Domains (3) summary

TIGR03230
Location:55 → 488

lipo_lipase; lipoprotein lipase

cd00707
Location:65 → 344

Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...

cd01758
Location:351 → 486

PLAT_LPL; PLAT/ LH2 domain present in lipoprotein lipase (LPL). LPL is a key enzyme in catabolism of plasma lipoprotein triglycerides (TGs) and has therefeore has a profound influence on triglyceride and high-density lipoprotein (HDL) cholesterol levels in the ...