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    eif4ebp2 eukaryotic translation initiation factor 4E binding protein 2 [ Danio rerio (zebrafish) ]

    Gene ID: 386945, updated on 9-Dec-2024

    Summary

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    Official Symbol
    eif4ebp2provided by ZNC
    Official Full Name
    eukaryotic translation initiation factor 4E binding protein 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-031118-83
    See related
    Ensembl:ENSDARG00000031819 AllianceGenome:ZFIN:ZDB-GENE-031118-83
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fa55e11; wu:fa55e11; wu:fp45e09
    Summary
    Predicted to enable eukaryotic initiation factor 4E binding activity. Predicted to be involved in negative regulation of translational initiation. Predicted to act upstream of or within negative regulation of translation and translational initiation. Predicted to be active in cytoplasm. Is expressed in brain and head. Orthologous to human EIF4EBP2 (eukaryotic translation initiation factor 4E binding protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See eif4ebp2 in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (30163548..30168897)
    105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (30033098..30038447)

    Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene secretion associated, Ras related GTPase 1Ab Neighboring gene inorganic pyrophosphatase 1b Neighboring gene phosphatase domain containing paladin 1b Neighboring gene pyroglutamylated RFamide peptide receptor a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Identification of 3' UTR motifs required for mRNA localization to myelin sheaths in vivo. Yergert KM, et al. PLoS Biol, 2021 Jan. PMID 33439856, Free PMC Article
    2. The evolutionary origin of nodal-related genes in teleosts. Fan X, et al. Dev Genes Evol, 2007 Dec. PMID 17992538
    3. Roles of mRNA fate modulators Dhh1 and Pat1 in TNRC6-dependent gene silencing recapitulated in yeast. Makino S, et al. J Biol Chem, 2015 Mar 27. PMID 25657010, Free PMC Article
    4. Codon Usage and 3' UTR Length Determine Maternal mRNA Stability in Zebrafish. Mishima Y, et al. Mol Cell, 2016 Mar 17. PMID 26990990
    5. eIF4EBP3L acts as a gatekeeper of TORC1 in activity-dependent muscle growth by specifically regulating Mef2ca translational initiation. Yogev O, et al. PLoS Biol, 2013 Oct. PMID 24143132, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables eukaryotic initiation factor 4E binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables eukaryotic initiation factor 4E binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables translation initiation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of translational initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of translational initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within translational initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    eukaryotic translation initiation factor 4E-binding protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_212803.1 → NP_997968.1  eukaryotic translation initiation factor 4E-binding protein 2

      See identical proteins and their annotated locations for NP_997968.1

      Status: PROVISIONAL

      Source sequence(s)
      BC066546
      UniProtKB/TrEMBL
      A0A8M1PFQ8, Q6NYL2
      Related
      ENSDARP00000040925.4, ENSDART00000040926.5
      Conserved Domains (1) summary
      pfam05456
      Location:9 → 113
      eIF_4EBP; Eukaryotic translation initiation factor 4E binding protein (EIF4EBP)

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007124.7 Reference GRCz11 Primary Assembly

      Range
      30163548..30168897
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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