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    trip13 thyroid hormone receptor interactor 13 [ Danio rerio (zebrafish) ]

    Gene ID: 393554, updated on 9-Dec-2024

    Summary

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    Official Symbol
    trip13provided by ZNC
    Official Full Name
    thyroid hormone receptor interactor 13provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-1488
    See related
    Ensembl:ENSDARG00000025043 AllianceGenome:ZFIN:ZDB-GENE-040426-1488
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:65952; im:6901078
    Summary
    Predicted to enable ATP binding activity and ATP hydrolysis activity. Predicted to be involved in several processes, including double-strand break repair; meiosis I; and meiotic recombination checkpoint signaling. Predicted to act upstream of or within cell differentiation and meiotic cell cycle. Predicted to be active in chromosome and nucleus. Human ortholog(s) of this gene implicated in mosaic variegated aneuploidy syndrome 3. Orthologous to human TRIP13 (thyroid hormone receptor interactor 13). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See trip13 in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (52966843..52991485)
    105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (53079057..53103713)

    Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene zinc finger DHHC-type containing 11 Neighboring gene bromodomain containing 9 Neighboring gene NKD inhibitor of WNT signaling pathway 2b Neighboring gene zgc:158766 Neighboring gene uncharacterized LOC101885705

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Distinct Molecular Signature of Murine Fetal Liver and Adult Hematopoietic Stem Cells Identify Novel Regulators of Hematopoietic Stem Cell Function. Manesia JK, et al. Stem Cells Dev, 2017 Apr 15. PMID 27958775, Free PMC Article
    2. Dhx38 is required for the maintenance and differentiation of erythro-myeloid progenitors and hematopoietic stem cells by alternative splicing. Tu J, et al. Development, 2022 Sep 1. PMID 35929537
    3. Unexpected novel relational links uncovered by extensive developmental profiling of nuclear receptor expression. Bertrand S, et al. PLoS Genet, 2007 Nov. PMID 17997606, Free PMC Article
    4. Many genes in fish have species-specific asymmetric rates of molecular evolution. Steinke D, et al. BMC Genomics, 2006 Feb 8. PMID 16466575, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC65952

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in anatomical structure morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in double-strand break repair ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in meiotic recombination checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within oogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in oogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in reciprocal meiotic recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in reciprocal meiotic recombination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in reciprocal meiotic recombination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spermatogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in synaptonemal complex assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in chromosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    pachytene checkpoint protein 2 homolog
    Names
    TR-interacting protein 13 homolog
    TRIP-13 homolog
    thyroid hormone receptor interactor 13 homolog
    thyroid receptor-interacting protein 13 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200582.1 → NP_956876.1  pachytene checkpoint protein 2 homolog

      See identical proteins and their annotated locations for NP_956876.1

      Status: PROVISIONAL

      Source sequence(s)
      BC056713
      UniProtKB/Swiss-Prot
      Q6PH52
      Related
      ENSDARP00000049098.5, ENSDART00000049099.7
      Conserved Domains (2) summary
      smart00382
      Location:164 → 314
      AAA; ATPases associated with a variety of cellular activities
      pfam00004
      Location:167 → 312
      AAA; ATPase family associated with various cellular activities (AAA)

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007127.7 Reference GRCz11 Primary Assembly

      Range
      52966843..52991485
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005170125.5 → XP_005170182.1  pachytene checkpoint protein 2 homolog isoform X1

      UniProtKB/TrEMBL
      A0A8M2BHH9, F1RBS4
      Conserved Domains (2) summary
      smart00382
      Location:164 → 314
      AAA; ATPases associated with a variety of cellular activities
      pfam00004
      Location:167 → 312
      AAA; ATPase family associated with various cellular activities (AAA)

    2. XM_017351326.3 → XP_017206815.1  pachytene checkpoint protein 2 homolog isoform X1

      UniProtKB/TrEMBL
      A0A8M2BHH9, F1RBS4
      Conserved Domains (2) summary
      smart00382
      Location:164 → 314
      AAA; ATPases associated with a variety of cellular activities
      pfam00004
      Location:167 → 312
      AAA; ATPase family associated with various cellular activities (AAA)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6PH52.1 GenPept UniProtKB/Swiss-Prot:Q6PH52

    Gene LinkOut

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