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    hxk-1 Phosphotransferase [ Caenorhabditis elegans ]

    Gene ID: 172751, updated on 9-Dec-2024

    Summary

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    Official Symbol
    hxk-1
    Official Full Name
    Phosphotransferase
    Primary source
    WormBase:WBGene00008780
    Locus tag
    CELE_F14B4.2
    See related
    AllianceGenome:WB:WBGene00008780
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable fructokinase activity and glucokinase activity. Predicted to be involved in several processes, including glucose 6-phosphate metabolic process; glycolytic process; and intracellular glucose homeostasis. Predicted to be active in cytosol and mitochondrion. Human ortholog(s) of this gene implicated in several diseases, including Charcot-Marie-Tooth disease type 4G; anemia (multiple); artery disease (multiple); glucose metabolism disease (multiple); and hematologic cancer (multiple). Orthologous to several human genes including GCK (glucokinase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See hxk-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    8
    Sequence:
    Chromosome: I; NC_003279.8 (9271479..9278689, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene EGF-like domain-containing protein Neighboring gene tRNA-Arg Neighboring gene tRNA-Pro Neighboring gene ncRNA Neighboring gene DNA-directed RNA polymerase I subunit RPA2 homolog Neighboring gene DUF305 domain-containing protein;F-box domain-containing protein Neighboring gene Phosphatase and actin regulator 2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Toxicity and metabolism of 3-bromopyruvate in Caenorhabditis elegans. Gu QL, et al. J Zhejiang Univ Sci B, 2020 Jan.. PMID 31898444, Free PMC Article
    2. MRG-1, an autosome-associated protein, silences X-linked genes and protects germline immortality in Caenorhabditis elegans. Takasaki T, et al. Development, 2007 Feb. PMID 17215300, Free PMC Article
    3. MES-4: an autosome-associated histone methyltransferase that participates in silencing the X chromosomes in the C. elegans germ line. Bender LB, et al. Development, 2006 Oct. PMID 16968818, Free PMC Article
    4. Glyceraldehyde-3-phosphate dehydrogenase mediates anoxia response and survival in Caenorhabditis elegans. Mendenhall AR, et al. Genetics, 2006 Nov. PMID 16980394, Free PMC Article
    5. A novel biochemical method to identify target genes of individual microRNAs: identification of a new Caenorhabditis elegans let-7 target. Andachi Y. RNA, 2008 Nov. PMID 18824511, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables D-glucose binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables fructokinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables fructokinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glucokinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glucokinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hexokinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphotransferase activity, alcohol group as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glucose 6-phosphate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glucose metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycolytic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycolytic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in hexose metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular glucose homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular glucose homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Phosphotransferase
    NP_001021106.1
    • Confirmed by transcript evidence
    NP_001370182.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      9271479..9278689 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001383604.2 → NP_001370182.1  Phosphotransferase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6BET1
      Conserved Domains (1) summary
      COG5026
      Location:16 → 482
      COG5026; Hexokinase [Carbohydrate transport and metabolism]

    2. NM_001025935.5 → NP_001021106.1  Phosphotransferase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021106.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q19440
      Conserved Domains (3) summary
      COG5026
      Location:37 → 487
      COG5026; Hexokinase [Carbohydrate transport and metabolism]
      pfam00349
      Location:39 → 233
      Hexokinase_1; Hexokinase
      pfam03727
      Location:239 → 480
      Hexokinase_2; Hexokinase
    Nucleotide Protein
    Heading Accession and Version

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