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    ephb2b eph receptor B2b [ Danio rerio (zebrafish) ]

    Gene ID: 554232, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ephb2bprovided by ZNC
    Official Full Name
    eph receptor B2bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050522-415
    See related
    Ensembl:ENSDARG00000021539 AllianceGenome:ZFIN:ZDB-GENE-050522-415
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    tpx2; fi18g12; wu:fb09e10; wu:fc64a03; wu:fi18g12; zgc:112296
    Summary
    Predicted to enable transmembrane-ephrin receptor activity. Predicted to be involved in axon guidance and ephrin receptor signaling pathway. Predicted to act upstream of or within cell surface receptor protein tyrosine kinase signaling pathway and protein phosphorylation. Predicted to be located in membrane. Predicted to be active in dendrite and plasma membrane. Is expressed in diencephalon and optic stalk. Human ortholog(s) of this gene implicated in blood platelet disease. Orthologous to human EPHB2 (EPH receptor B2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ephb2b in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (28218141..28424181)
    105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (27970967..28177007)

    Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene neuromedin U receptor 3 Neighboring gene lactamase, beta-like 1b Neighboring gene leucine rich repeat containing 38b Neighboring gene leucine-rich repeat-containing protein 38-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Investigation of alpl expression and Tnap-activity in zebrafish implies conserved functions during skeletal and neuronal development. Ohlebusch B, et al. Sci Rep, 2020 Aug 7. PMID 32770041, Free PMC Article
    2. MicroRNA-10a/10b represses a novel target gene mib1 to regulate angiogenesis. Wang X, et al. Cardiovasc Res, 2016 May 1. PMID 26825552
    3. Toxicity of triphenyltin on the development of retinal axons in zebrafish at low dose. Xiao Y, et al. Aquat Toxicol, 2017 Aug. PMID 28558289
    4. Flt1 acts as a negative regulator of tip cell formation and branching morphogenesis in the zebrafish embryo. Krueger J, et al. Development, 2011 May. PMID 21521739, Free PMC Article
    5. DNA methyltransferase 1 functions through C/ebpa to maintain hematopoietic stem and progenitor cells in zebrafish. Liu X, et al. J Hematol Oncol, 2015 Feb 22. PMID 25886310, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC112296

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ephrin receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane receptor protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane-ephrin receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cell surface receptor protein tyrosine kinase signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ephrin receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ephrin type-B receptor 2b
    Names
    TPX2, microtubule-associated, homolog
    NP_001314672.1
    XP_021335297.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001327743.1 → NP_001314672.1  ephrin type-B receptor 2b precursor

      Status: VALIDATED

      Source sequence(s)
      CR450786, CR846088
      UniProtKB/TrEMBL
      A0A8M1P981, A2CEJ3
      Related
      ENSDARP00000043755.7, ENSDART00000043756.9

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007122.7 Reference GRCz11 Primary Assembly

      Range
      28218141..28424181
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021479622.2 → XP_021335297.1  ephrin type-B receptor 2b isoform X1

      UniProtKB/TrEMBL
      A0A8M9PUX4
      Conserved Domains (5) summary
      cd05065
      Location:619 → 887
      PTKc_EphR_B; Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors
      cd10477
      Location:17 → 199
      EphR_LBD_B2; Ligand Binding Domain of Ephrin type-B Receptor 2
      pfam00041
      Location:440 → 523
      fn3; Fibronectin type III domain
      pfam14575
      Location:551 → 619
      EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
      cl15755
      Location:892 → 931
      SAM_superfamily; SAM (Sterile alpha motif )

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001033094.1: Suppressed sequence

      Description
      NM_001033094.1: This RefSeq was removed because it was based on a chimeric sequence.
    Nucleotide Protein Strain
    Heading Accession and Version

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