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    mipepb mitochondrial intermediate peptidase b [ Danio rerio (zebrafish) ]

    Gene ID: 557349, updated on 9-Dec-2024

    Summary

    Official Symbol
    mipepbprovided by ZNC
    Official Full Name
    mitochondrial intermediate peptidase bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050506-64
    See related
    Ensembl:ENSDARG00000055339 AllianceGenome:ZFIN:ZDB-GENE-050506-64
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    im:6903007; si:ch73-1a9.4
    Summary
    Predicted to enable metalloendopeptidase activity. Predicted to be involved in peptide metabolic process and protein processing involved in protein targeting to mitochondrion. Predicted to act upstream of or within proteolysis. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 31. Orthologous to human MIPEP (mitochondrial intermediate peptidase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See mipepb in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 10 NC_007121.7 (39091532..39123211)
    105 previous assembly GRCz10 (GCF_000002035.5) 10 NC_007121.6 (39148238..39179933)

    Chromosome 10 - NC_007121.7Genomic Context describing neighboring genes Neighboring gene immunoglobulin superfamily, member 5a Neighboring gene high mobility group nucleosome binding domain 1b Neighboring gene DNA ligase 1-like Neighboring gene ribosomal protein S25 Neighboring gene solute carrier family 37 member 4b

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    General gene information

    Markers

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in peptide metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein processing involved in protein targeting to mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    mitochondrial intermediate peptidase

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007121.7 Reference GRCz11 Primary Assembly

      Range
      39091532..39123211
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_680404.8XP_685496.2  mitochondrial intermediate peptidase isoform X1

      UniProtKB/TrEMBL
      A0A8N7TDA3, F1QIA6
      Related
      ENSDARP00000111708.2, ENSDART00000125986.3
      Conserved Domains (2) summary
      cd06457
      Location:37668
      M3A_MIP; Peptidase M3 mitochondrial intermediate peptidase (MIP)
      COG0339
      Location:47664
      Dcp; Zn-dependent oligopeptidase [Posttranslational modification, protein turnover, chaperones]
    2. XM_021479450.2XP_021335125.1  mitochondrial intermediate peptidase isoform X2

      UniProtKB/TrEMBL
      A0A2R8QM23, A0A8M9QLA4
      Related
      ENSDARP00000153621.1, ENSDART00000193072.1
      Conserved Domains (1) summary
      cd06457
      Location:37643
      M3A_MIP; Peptidase M3 mitochondrial intermediate peptidase (MIP)