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    gatad2ab GATA zinc finger domain containing 2Ab [ Danio rerio (zebrafish) ]

    Gene ID: 405852, updated on 9-Dec-2024

    Summary

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    Official Symbol
    gatad2abprovided by ZNC
    Official Full Name
    GATA zinc finger domain containing 2Abprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-2372
    See related
    Ensembl:ENSDARG00000006192 AllianceGenome:ZFIN:ZDB-GENE-040426-2372
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    gatad2a; zgc:85938; ns:zf-a189
    Summary
    Predicted to enable metal ion binding activity and sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be located in nucleus. Predicted to be part of NuRD complex. Orthologous to human GATAD2A (GATA zinc finger domain containing 2A). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See gatad2ab in Genome Data Viewer
    Location:
    chromosome: 22
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 22 NC_007133.7 (18316133..18384722)
    105 previous assembly GRCz10 (GCF_000002035.5) 22 NC_007133.6 (18291179..18359443)

    Chromosome 22 - NC_007133.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 161A Neighboring gene uncharacterized LOC110438274 Neighboring gene microRNA 9-4 Neighboring gene uncharacterized LOC103909585 Neighboring gene YjeF N-terminal domain containing 3 Neighboring gene testis-specific serine kinase 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Rapid identification and isolation of zebrafish cDNA clones. Gong Z, et al. Gene, 1997 Nov 12. PMID 9409775
    2. Assignment of Functional Relevance to Genes at Type 2 Diabetes-Associated Loci Through Investigation of β-Cell Mass Deficits. O'Hare EA, et al. Mol Endocrinol, 2016 Apr. PMID 26963759, Free PMC Article
    3. Phenotypic Landscape of Schizophrenia-Associated Genes Defines Candidates and Their Shared Functions. Thyme SB, et al. Cell, 2019 Apr 4. PMID 30929901, Free PMC Article
    4. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
    5. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC85938

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of NuRD complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    GATA zinc finger domain containing 2Ab
    Names
    GATA zinc finger domain containing 2A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_212916.1 → NP_998081.1  GATA zinc finger domain containing 2Ab

      See identical proteins and their annotated locations for NP_998081.1

      Status: PROVISIONAL

      Source sequence(s)
      BC067707
      UniProtKB/TrEMBL
      Q6NW66
      Related
      ENSDARP00000031168.6, ENSDART00000033103.7
      Conserved Domains (2) summary
      pfam00320
      Location:399 → 434
      GATA; GATA zinc finger
      pfam16563
      Location:130 → 166
      P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007133.7 Reference GRCz11 Primary Assembly

      Range
      18316133..18384722
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005170444.5 → XP_005170501.1  GATA zinc finger domain containing 2Ab isoform X1

      UniProtKB/TrEMBL
      A0A0R4IN87, A0A8M2BHS7
      Related
      ENSDARP00000135963.2, ENSDART00000160413.2
      Conserved Domains (3) summary
      pfam00320
      Location:522 → 557
      GATA; GATA zinc finger
      pfam05485
      Location:6 → 95
      THAP; THAP domain
      pfam16563
      Location:246 → 282
      P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2

    2. XM_005170446.5 → XP_005170503.1  GATA zinc finger domain containing 2Ab isoform X3

      UniProtKB/TrEMBL
      A0A8M2BHS5
      Conserved Domains (3) summary
      pfam00320
      Location:522 → 557
      GATA; GATA zinc finger
      pfam05485
      Location:6 → 95
      THAP; THAP domain
      pfam16563
      Location:246 → 282
      P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2

    3. XM_005170445.5 → XP_005170502.1  GATA zinc finger domain containing 2Ab isoform X2

      UniProtKB/TrEMBL
      A0A8M2BHS0
      Conserved Domains (3) summary
      pfam00320
      Location:515 → 550
      GATA; GATA zinc finger
      pfam05485
      Location:6 → 95
      THAP; THAP domain
      pfam16563
      Location:246 → 282
      P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2

    4. XM_068216268.1 → XP_068072369.1  GATA zinc finger domain containing 2Ab isoform X4

    5. XM_005170448.5 → XP_005170505.1  GATA zinc finger domain containing 2Ab isoform X6

      UniProtKB/TrEMBL
      A0A2R8QD88, A0A8M2BI68
      Related
      ENSDARP00000150981.1, ENSDART00000184649.1
      Conserved Domains (2) summary
      pfam00320
      Location:406 → 441
      GATA; GATA zinc finger
      pfam16563
      Location:130 → 166
      P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2

    6. XM_068216270.1 → XP_068072371.1  GATA zinc finger domain containing 2Ab isoform X7

    7. XM_068216269.1 → XP_068072370.1  GATA zinc finger domain containing 2Ab isoform X6

      UniProtKB/TrEMBL
      A0A2R8QD88, A0A8M2BI68

    8. XM_005170447.5 → XP_005170504.2  GATA zinc finger domain containing 2Ab isoform X5

      UniProtKB/TrEMBL
      A0A8M2BHR2
      Related
      ENSDARP00000147496.1, ENSDART00000186580.1
      Conserved Domains (2) summary
      pfam00320
      Location:448 → 483
      GATA; GATA zinc finger
      pfam16563
      Location:172 → 208
      P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2
    Nucleotide Protein
    Heading Accession and Version

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