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    pou3f3a POU class 3 homeobox 3a [ Danio rerio (zebrafish) ]

    Gene ID: 30386, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pou3f3aprovided by ZNC
    Official Full Name
    POU class 3 homeobox 3aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-980526-220
    See related
    Ensembl:ENSDARG00000042032 AllianceGenome:ZFIN:ZDB-GENE-980526-220
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zp12; pou12; brn1.1; BRN-1.1; ZP12POU; wu:fc33a11
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within brain development and regulation of DNA-templated transcription. Predicted to be located in nucleus. Is expressed in central nervous system; neural tube; neurons; pharyngeal arch; and pronephric duct. Orthologous to human POU3F3 (POU class 3 homeobox 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See pou3f3a in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (6658594..6661699, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (6680609..6683714, complement)

    Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene si:dkeyp-118h3.6 Neighboring gene G protein-coupled receptor 45 Neighboring gene uncharacterized LOC137496442 Neighboring gene uncharacterized LOC137496443

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Developmental expression of class III and IV POU domain genes in the zebrafish. Sampath K, et al. Biochem Biophys Res Commun, 1996 Feb 15. PMID 8605028
    2. Molecular phylogeny and functional genomics of beta-galactoside alpha2,6-sialyltransferases that explain ubiquitous expression of st6gal1 gene in amniotes. Petit D, et al. J Biol Chem, 2010 Dec 3. PMID 20855889, Free PMC Article
    3. Combinatorial expression of zebrafish Brn-1- and Brn-2-related POU genes in the embryonic brain, pronephric primordium, and pharyngeal arches. Hauptmann G, et al. Dev Dyn, 2000 Jun. PMID 10842361
    4. Evolution of vertebrate gill covers via shifts in an ancient Pou3f3 enhancer. Barske L, et al. Proc Natl Acad Sci U S A, 2020 Oct 6. PMID 32958671, Free PMC Article
    5. The helix-loop-helix protein id1 controls stem cell proliferation during regenerative neurogenesis in the adult zebrafish telencephalon. Rodriguez Viales R, et al. Stem Cells, 2015 Mar. PMID 25376791

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC192422

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within brain development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    POU domain, class 3, transcription factor 3-A
    Names
    POU domain gene 12
    POU domain protein 12
    POU domain protein zp-12
    ZP-12
    brain POU domain gene 1.1
    brain-1.1
    brain-specific homeobox/POU domain protein 1.1
    class III POU domain protein taichi
    zfbrn-1.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001312687.1 → NP_001299616.1  POU domain, class 3, transcription factor 3-A isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region that results in a frame-shift compared to variant 1. It encodes isoform 2, which is shorter than and has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      BC058318, BX842683
      UniProtKB/Swiss-Prot
      B0S7I5, B0S7I6, B0S7I7, B5DDP9, O57514, P56224, Q6IS23, Q6NZU9, Q6PE22, Q7ZU57, Q90433, Q90436
      Related
      ENSDARP00000103222.3, ENSDART00000113914.4
      Conserved Domains (2) summary
      smart00352
      Location:242 → 316
      POU; Found in Pit-Oct-Unc transcription factors
      pfam00046
      Location:337 → 390
      Homeobox; Homeobox domain

    2. NM_131150.2 → NP_571225.2  POU domain, class 3, transcription factor 3-A isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      BC058318, BC065961, BX842683
      UniProtKB/Swiss-Prot
      P56224
      Related
      ENSDARP00000061592.2, ENSDART00000061593.3
      Conserved Domains (2) summary
      smart00352
      Location:242 → 316
      POU; Found in Pit-Oct-Unc transcription factors
      pfam00046
      Location:337 → 390
      Homeobox; Homeobox domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007120.7 Reference GRCz11 Primary Assembly

      Range
      6658594..6661699 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P56224.2 GenPept UniProtKB/Swiss-Prot:P56224

    Gene LinkOut

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