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    cth cystathionase (cystathionine gamma-lyase) [ Danio rerio (zebrafish) ]

    Gene ID: 322055, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cthprovided by ZNC
    Official Full Name
    cystathionase (cystathionine gamma-lyase)provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-774
    See related
    Ensembl:ENSDARG00000074301 AllianceGenome:ZFIN:ZDB-GENE-030131-774
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fb58d08; zgc:66001; zgc:85785; wu:fb48e03; wu:fb58d08
    Summary
    Predicted to enable cystathionine gamma-lyase activity and pyridoxal phosphate binding activity. Predicted to be involved in cysteine biosynthetic process via cystathionine and transsulfuration. Predicted to act upstream of or within cysteine biosynthetic process. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in amino acid metabolic disorder and cystathioninuria. Orthologous to human CTH (cystathionine gamma-lyase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See cth in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (37409558..37422947, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (37431664..37445053, complement)

    Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137495991 Neighboring gene cystathionase (cystathionine gamma-lyase), like Neighboring gene nitrilase family, member 2 Neighboring gene si:dkey-66a8.7 Neighboring gene GTP binding protein 6 (putative)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. The role of hydrogen sulphide in the control of breathing in hypoxic zebrafish (Danio rerio). Porteus CS, et al. J Physiol, 2014 Jul 15. PMID 24756639, Free PMC Article
    2. Hydrogen sulfide inhibits Na+ uptake in larval zebrafish, Danio rerio. Kumai Y, et al. Pflugers Arch, 2015 Apr. PMID 24939700
    3. H(2)S promotes developmental brain angiogenesis via the NOS/NO pathway in zebrafish. Jiang W, et al. Stroke Vasc Neurol, 2021 Jun. PMID 33246971, Free PMC Article
    4. Zebrafish, a Novel Model System to Study Uremic Toxins: The Case for the Sulfur Amino Acid Lanthionine. Perna AF, et al. Int J Mol Sci, 2018 Apr 29. PMID 29710830, Free PMC Article
    5. Hydrogen sulfide promotes calcium uptake in larval zebrafish. Kwong RW, et al. Am J Physiol Cell Physiol, 2015 Jul 1. PMID 25948733, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables L-cysteine desulfhydrase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables L-cystine L-cysteine-lyase (deaminating) IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cystathionine gamma-lyase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cystathionine gamma-lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pyridoxal phosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within amino acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cysteine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cysteine biosynthetic process via cystathionine IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transsulfuration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within transsulfuration IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cystathionine gamma-lyase
    NP_997769.3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_212604.3 → NP_997769.3  cystathionine gamma-lyase

      Status: VALIDATED

      Source sequence(s)
      BX324166, EH493556, EH596437
      UniProtKB/TrEMBL
      A0A8M1PHM3, F1QPF7
      Related
      ENSDARP00000117293.1, ENSDART00000138351.2
      Conserved Domains (2) summary
      PRK08776
      Location:19 → 400
      PRK08776; cystathionine gamma-synthase; Provisional
      pfam01053
      Location:21 → 397
      Cys_Met_Meta_PP; Cys/Met metabolizm PLP-dependent enzyme

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007117.7 Reference GRCz11 Primary Assembly

      Range
      37409558..37422947 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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