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    spint1a serine peptidase inhibitor, Kunitz type 1 a [ Danio rerio (zebrafish) ]

    Gene ID: 406426, updated on 27-Dec-2024

    Summary

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    Official Symbol
    spint1aprovided by ZNC
    Official Full Name
    serine peptidase inhibitor, Kunitz type 1 aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-2169
    See related
    Ensembl:ENSDARG00000102332 AllianceGenome:ZFIN:ZDB-GENE-040426-2169
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    cb376; spint1l; sb:cb376; zgc:64075
    Summary
    Enables peptidase inhibitor activity. Involved in regulation of inflammatory response. Acts upstream of or within several processes, including collagen fibril organization; epidermis development; and neutrophil chemotaxis. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including apical ectodermal ridge; digestive system; fin fold pectoral fin bud; periderm; and sensory system. Used to study psoriasis. Orthologous to human SPINT1 (serine peptidase inhibitor, Kunitz type 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See spint1a in Genome Data Viewer
    Location:
    chromosome: 17
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (1999526..2039487, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (1922247..1946146, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) Unplaced Scaffold NW_008805411.1 (102768..131055)

    Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene pleckstrin homology domain-containing family G member 3 Neighboring gene adhesion G-protein coupled receptor G2 Neighboring gene protein phosphatase 1 regulatory inhibitor subunit 14D Neighboring gene zinc finger, FYVE domain containing 19

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Skin exposure to micro- and nano-particles can cause haemostasis in zebrafish larvae. McLeish JA, et al. Thromb Haemost, 2010 Apr. PMID 20174755
    2. Gasdermin E mediates pyroptotic cell death of neutrophils and macrophages in a zebrafish model of chronic skin inflammation. Lozano-Gil JM, et al. Dev Comp Immunol, 2022 Jul. PMID 35341794
    3. Live imaging of chronic inflammation caused by mutation of zebrafish Hai1. Mathias JR, et al. J Cell Sci, 2007 Oct 1. PMID 17881499
    4. Matrix metalloproteinase 9 modulates collagen matrices and wound repair. LeBert DC, et al. Development, 2015 Jun 15. PMID 26015541, Free PMC Article
    5. ZAKα/P38 kinase signaling pathway regulates hematopoiesis by activating the NLRP1 inflammasome. Rodríguez-Ruiz L, et al. EMBO Mol Med, 2023 Oct 11. PMID 37675820, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Entosis and apical cell extrusion constitute a tumor-suppressive mechanism downstream of Matriptase.
      Title: Entosis and apical cell extrusion constitute a tumor-suppressive mechanism downstream of Matriptase.
    2. Results describe the live imaging of chronic inflammation caused by mutation of zebrafish Hai1.
      Title: Live imaging of chronic inflammation caused by mutation of zebrafish Hai1.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables peptidase inhibitor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables serine-type endopeptidase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of cell population proliferation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within cell population proliferation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within collagen fibril organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in epidermis development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within epidermis development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within epidermis development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in epithelium development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within epithelium development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in extracellular matrix organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within morphogenesis of an epithelium IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within morphogenesis of an epithelium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within neutrophil chemotaxis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    kunitz-type protease inhibitor 1a
    Names
    hai1a
    serine protease inhibitor HGFAI
    serine protease inhibitor, Kunitz type 1 b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_213152.1 → NP_998317.1  kunitz-type protease inhibitor 1a precursor

      See identical proteins and their annotated locations for NP_998317.1

      Status: PROVISIONAL

      Source sequence(s)
      BC053239
      UniProtKB/TrEMBL
      A0A2R8QCE4, A0A8M9PKM6, Q7T363
      Related
      ENSDARP00000136123.2, ENSDART00000160223.2
      Conserved Domains (4) summary
      smart00089
      Location:149 → 229
      PKD; Repeats in polycystic kidney disease 1 (PKD1) and other proteins
      cd00112
      Location:321 → 355
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      pfam00014
      Location:376 → 427
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam07502
      Location:33 → 120
      MANEC; MANEC domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007128.7 Reference GRCz11 Primary Assembly

      Range
      1999526..2039487 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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