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    rmd-2 TPR_REGION domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 179391, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rmd-2
    Official Full Name
    TPR_REGION domain-containing protein
    Primary source
    WormBase:WBGene00007786
    Locus tag
    CELE_C27H6.4
    See related
    AllianceGenome:WB:WBGene00007786
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable microtubule binding activity. Predicted to be located in membrane. Predicted to be active in mitochondrion; mitotic spindle pole; and spindle microtubule. Orthologous to human RMDN2 (regulator of microtubule dynamics 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See rmd-2 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    7
    Sequence:
    Chromosome: V; NC_003283.11 (9983919..9986277, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene RuvB-like 1 Neighboring gene Schlafen-like protein 1 Neighboring gene Mitochondrial genome maintenance exonuclease 1 Neighboring gene MYG1 protein C27H6.8 Neighboring gene Piwi domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Paternal mitochondria from an rmd-2, rmd-3, rmd-6 triple mutant are properly positioned in the C. elegans zygote. Juanico IY, et al. MicroPubl Biol, 2021. PMID 34296068, Free PMC Article
    2. Global Proteomic Response of Caenorhabditis elegans Against PemK(Sa) Toxin. Mir DA, et al. Front Cell Infect Microbiol, 2019. PMID 31214513, Free PMC Article
    3. An integrated strategy to study muscle development and myofilament structure in Caenorhabditis elegans. Meissner B, et al. PLoS Genet, 2009 Jun. PMID 19557190, Free PMC Article
    4. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article
    5. Depletion of endogenously biotinylated carboxylases enhances the sensitivity of TurboID-mediated proximity labeling in Caenorhabditis elegans. Artan M, et al. J Biol Chem, 2022 Sep. PMID 35933017, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in intracellular organelle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitotic spindle pole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in spindle microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    TPR_REGION domain-containing protein
    NP_001122866.1
    • Confirmed by transcript evidence
    NP_741608.2
    • Confirmed by transcript evidence
    NP_741609.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      9983919..9986277 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_171523.6 → NP_741609.1  TPR_REGION domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741609.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      P90762
      Conserved Domains (3) summary
      PRK11447
      Location:205 → 257
      PRK11447; cellulose synthase subunit BcsC; Provisional
      TIGR02917
      Location:140 → 262
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:222 → 250
      TPR; TPR repeat [structural motif]

    2. NM_171522.7 → NP_741608.2  TPR_REGION domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741608.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MQB5
      Conserved Domains (3) summary
      PRK11447
      Location:311 → 363
      PRK11447; cellulose synthase subunit BcsC; Provisional
      TIGR02917
      Location:246 → 368
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:273 → 323
      TPR; TPR repeat [structural motif]

    3. NM_001129394.5 → NP_001122866.1  TPR_REGION domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001122866.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B2D6P1
      Conserved Domains (3) summary
      PRK11447
      Location:158 → 210
      PRK11447; cellulose synthase subunit BcsC; Provisional
      TIGR02917
      Location:93 → 215
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:175 → 203
      TPR; TPR repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version

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