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    dync1li2 dynein, cytoplasmic 1, light intermediate chain 2 [ Danio rerio (zebrafish) ]

    Gene ID: 573266, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dync1li2provided by ZNC
    Official Full Name
    dynein, cytoplasmic 1, light intermediate chain 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050417-156
    See related
    Ensembl:ENSDARG00000035924 AllianceGenome:ZFIN:ZDB-GENE-050417-156
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fc08b04; wu:fc08b04; zgc:112480
    Summary
    Predicted to enable dynein heavy chain binding activity. Acts upstream of or within regulation of metaphase plate congression; regulation of mitotic cell cycle, embryonic; and regulation of mitotic spindle organization. Predicted to be located in cytoplasm and microtubule. Predicted to be part of cytoplasmic dynein complex. Predicted to colocalize with centrosome. Orthologous to human DYNC1LI2 (dynein cytoplasmic 1 light intermediate chain 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See dync1li2 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (44674956..44704877, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (44336221..44365682, complement)

    Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137496202 Neighboring gene CKLF-like MARVEL transmembrane domain containing 3 Neighboring gene CKLF-like MARVEL transmembrane domain containing 4 Neighboring gene uncharacterized LOC103911411 Neighboring gene si:dkey-56m19.5 Neighboring gene uncharacterized LOC108190699

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. The Light Intermediate Chain 2 Subpopulation of Dynein Regulates Mitotic Spindle Orientation. Mahale S, et al. Sci Rep, 2016 Dec 23. PMID 28003657, Free PMC Article
    2. Polarized endosome dynamics engage cytoplasmic Par-3 that recruits dynein during asymmetric cell division. Zhao X, et al. Sci Adv, 2021 Jun. PMID 34117063, Free PMC Article
    3. Regulation of mitochondria-dynactin interaction and mitochondrial retrograde transport in axons. Drerup CM, et al. Elife, 2017 Apr 17. PMID 28414272, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC112480, MGC174291

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dynein heavy chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule-based movement IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within microtubule-based movement IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of metaphase plate congression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of mitotic cell cycle, embryonic IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of mitotic spindle organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    colocalizes_with centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of cytoplasmic dynein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytoplasmic dynein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of dynein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cytoplasmic dynein 1 light intermediate chain 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001017669.2 → NP_001017669.2  cytoplasmic dynein 1 light intermediate chain 2

      Status: VALIDATED

      Source sequence(s)
      BX511128, CK026114
      UniProtKB/TrEMBL
      A0A8M1N5F3, F1RB89
      Related
      ENSDARP00000031864.7, ENSDART00000037850.8
      Conserved Domains (3) summary
      cd00882
      Location:219 → 284
      Ras_like_GTPase; Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases)
      pfam05783
      Location:26 → 493
      DLIC; Dynein light intermediate chain (DLIC)
      cl21455
      Location:46 → 101
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007118.7 Reference GRCz11 Primary Assembly

      Range
      44674956..44704877 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005166450.5 → XP_005166507.1  cytoplasmic dynein 1 light intermediate chain 2 isoform X1

      UniProtKB/TrEMBL
      A0A8M2BDX2
      Conserved Domains (3) summary
      cd00882
      Location:219 → 284
      Ras_like_GTPase; Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases)
      pfam05783
      Location:26 → 465
      DLIC; Dynein light intermediate chain (DLIC)
      cl21455
      Location:46 → 101
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394706.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      171180..198206 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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