znfl2a zinc finger-like gene 2a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: znfl2aprovided by ZNC
Official Full Name: zinc finger-like gene 2aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030828-7
See related: Ensembl:ENSDARG00000008333 AllianceGenome:ZFIN:ZDB-GENE-030828-7
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: znfl2; YF-458; sb:cb490; wu:fe16e10; zgc:110491
Summary: Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; regulation of cytokine production; and regulation of immune system process. Predicted to be active in nucleoplasm. Is expressed in several structures, including hematopoietic system; margin; mesoderm; presumptive blood; and tail bud. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 2

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	2	NC_007113.7 (118226..122164, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	2	NC_007113.6 (129177..133115, complement)

Chromosome 2 - NC_007113.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The production of loss-of-function models for znfl2, znfl2b and znfl2/znfl2b together suggested that these erythrocyte specific zinc finger genes are dispensible for erythropoiesis.
Title: Characterisation of duplicate zinc finger like 2 erythroid precursor genes in zebrafish.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cytokine production	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of immune system process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: zinc finger-like gene 2a

Names: zinc finger-like gene 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_194390.2 → NP_919371.2 zinc finger-like gene 2a

Status: VALIDATED

Source sequence(s)

EH504227, EH530411

UniProtKB/TrEMBL

A0A8M1PCG8, F1QCE5

Related

ENSDARP00000012567.5, ENSDART00000004071.7

Conserved Domains (3) summary

COG5048
Location:93 → 246

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:94 → 114

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:106 → 131

zf-H2C2_2; Zinc-finger double domain