npp-14 Nuclear pore complex protein 14 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: npp-14
Official Full Name: Nuclear pore complex protein 14
Primary source: WormBase:WBGene00003800
Locus tag: CELE_C03D6.4
See related: AllianceGenome:WB:WBGene00003800
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables caspase binding activity. Involved in inhibition of cysteine-type endopeptidase activity involved in apoptotic process and negative regulation of execution phase of apoptosis. Predicted to be located in nuclear membrane. Predicted to be part of nuclear pore. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia; acute myeloid leukemia; and brain disease. Orthologous to human NUP214 (nucleoporin 214). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See npp-14 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 7

Sequence:: Chromosome: I; NC_003279.8 (9660174..9664915, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The nuclear-pore protein NPP-14 interacts with the CED-3 zymogen prodomain, colocalizes with CED-3 in vivo and inhibits CED-3 autoactivation in vitro.
Title: Regulation of CED-3 caspase localization and activation by C. elegans nuclear-membrane protein NPP-14.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C03D6.4 (e-PCR)
- UniSTS:306039

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables caspase binding	IPI Inferred from Physical Interaction more info	PubMed
enables nuclear localization sequence binding	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of nuclear pore	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in RNA export from nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in mRNA transport	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cysteine-type endopeptidase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of execution phase of apoptosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein import into nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear membrane	IEA Inferred from Electronic Annotation more info
part_of nuclear pore	IBA Inferred from Biological aspect of Ancestor more info
part_of nuclear pore	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Nuclear pore complex protein 14

NP_492568.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

9660174..9664915 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_060167.7 → NP_492568.1 Nuclear pore complex protein 14 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_492568.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q17602

Conserved Domains (3) summary

pfam16755
Location:271 → 400

NUP214; Nucleoporin or Nuclear pore complex subunit NUP214=Nup159

pfam13634
Location:1289 → 1373

Nucleoporin_FG; Nucleoporin FG repeat region

cl25732
Location:532 → 757

SMC_N; RecF/RecN/SMC N terminal domain